Ambroxol EP Impurity D HCl CAS 1384955-66-1
| CAS No. | 1384955-66-1 |
| Molecular Formula | C13H18Br2N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ambroxol EP Impurity D HCl (C13H18Br2N2OHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Ambroxol EP Impurity D HCl (CAS 1384955-66-1) is a certified pharmaceutical impurity reference standard with the molecular formula C13H18Br2N2OHCl and a molecular weight of 414.57 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ambroxol EP Impurity D HCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H18Br2N2O HCl |
| Molecular Weight | 414.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Ambroxol Standards
- Ambroxol Impurity 28 (Ambroxol Monobromo) (CAS 101900-43-0)
- Ambroxol Impurity 33 HCl (CAS 101900-44-1)
- Ambroxol impurity 61 (CAS 104670-74-8)
- Ambroxol impurity 68 (CAS 105735-86-2)
- Ambroxol EP Impurity D (CAS 107814-37-9)
- Ambroxol D5DISCONTINUED, offer A575902 (CAS 1246818-80-3)
- Ambroxol impurity 113 (CAS 131417-90-8)
- Ambroxol impurity 116 (CAS 1373889-89-4)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com