Ambroxol impurity 116 CAS 1373889-89-4
| CAS No. | 1373889-89-4 |
| Molecular Formula | C7H5Br2NO |
| Molecular Weight | 278.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 278.93 g/mol gives Ambroxol impurity 116 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ambroxol impurity 116 (CAS 1373889-89-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5Br2NO and a molecular weight of 278.93 g/mol.
The molecular framework of Ambroxol impurity 116 (C7H5Br2NO) is characterized by an amide group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ambroxol impurity 116 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5Br2NO |
| Molecular Weight | 278.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Ambroxol Standards
- Ambroxol Impurity 31 (CAS 42460-62-8)
- Ambroxol Impurity 49 (CAS 86379-71-7)
- Ambroxol EP Impurity A (CAS 50739-76-9)
- Ambroxol Impurity 20 (CAS 609-85-8)
- Ambroxol Impurity 37 (CAS CATO-C4X-108537)
- Ambroxol Impurity 83 (CAS CATO-C4X-108583)
- Ambroxol Impurity 28 (Ambroxol Monobromo) (CAS 101900-43-0)
- Ambroxol Impurity 85 (CAS CATO-C4X-108585)
Recommended Standards
- Bromhexine EP Impurity B (CAS 50910-55-9)
- 4,6-Dibromopicolinimidamide (CAS 2089327-49-9)
- ,2-dichloro-4-iodo-benzen;Benzene,1,2-dichloro-4-iodo-;3,4-Dichloro-1-iodobenzene 20555-91-3 3,4-Dichloroiodobenzene A20568 (CAS 20555-91-3)
- 3,5-Dibromo-2-methylisonicotinaldehyde (CAS 2504230-92-4)
- Tegoprazan Impurity 53 (CAS CATO-C4X-229753)
- Ribociclib Impurity 19 (CAS CATO-C4X-310019)
- Oxazepam EP impurity A (CAS 19554-95-1)
- 3,3-Dimethyl-1,4-oxathiane-2,6-dione (CAS 54772-29-1)
- Methyl 3-amino-2-((4-benzylpiperidin-1-yl)methyl)benzoate (CAS 860783-81-9)
- Samidorphan L-malate (CAS 1204592-75-5)
- (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH (salmon) Acetate (CAS 96497-82-4（free base）)
- 1-(3-Chloropyrazin-2-yl)pyrrolidin-3-ol (CAS 1343093-58-2)
- 3,3,3-Trifluoro-2-hydroxy-2-methylpropanenitrile (CAS 335-08-0)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com