Cetirizine Impurity C127 CAS 1391052-52-0
| CAS No. | 1391052-52-0 |
| Molecular Formula | C23H23ClN2O2S |
| Molecular Weight | 426.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Cetirizine Impurity C127 (CAS 1391052-52-0), a pharmacopoeial impurity reference standard (molecular formula C23H23ClN2O2S, MW 426.96 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Cetirizine Impurity C127 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 426.96 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cetirizine Impurity C127 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H23ClN2O2S |
| Molecular Weight | 426.96 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Cetirizine Standards
- Cetirizine EP Impurity E (CAS 682323-77-9)
- Cetirizine Dihydrochloride EP Impurity E (CAS CATO-C4X-108351)
- Cetirizine Impurity 30 (CAS CATO-C4X-158230)
- Cetirizine Impurity 29 (CAS 62084-35-9)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
- Cetirizine Impurity 17 (CAS CATO-C4X-158217)
- Cetirizine Impurity 16 (CAS CATO-C4X-158216)
- Cetirizine impurity 31 (CAS CATO-C4X-158231)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com