Haloperidol EP Impurity B CAS 1391052-53-1
| CAS No. | 1391052-53-1 |
| Molecular Formula | C21H23ClFNO2 |
| Molecular Weight | 375.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 375.86 g/mol gives Haloperidol EP Impurity B distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Haloperidol EP Impurity B (CAS 1391052-53-1) is a certified pharmaceutical impurity reference standard with the molecular formula C21H23ClFNO2 and a molecular weight of 375.86 g/mol.
Haloperidol EP Impurity B (C21H23ClFNO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Haloperidol EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H23ClFNO2 |
| Molecular Weight | 375.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol (CAS 52-86-8)
- Haloperidol Impurity 15 (CAS CATO-C4X-146115)
- Haloperidol-d4 (CAS 1189986-59-1)
- Haloperidol Impurity 22 (CAS 660844-75-7)
- Haloperidol impurity 25 (CAS 150214-94-1)
- Haloperidol Impurity 9 (CAS 148406-51-3)
- trans-Haloperidol N-Oxide (CAS 150214-93-0)
- Haloperidol Impurity 39 (CAS 52669-92-8)
Recommended Standards
- Epoxy resins (CAS 61788-97-4)
- Bdp5290 (CAS 1817698-21-7)
- 2-(4-Chlorophenyl)-3-(4-methylbenzoyl)-1,3-thiazolidine-4-carbohydrazide (CAS 1008281-47-7)
- H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CAS 154121-70-7)
- Bromocriptine Impurity 11 (CAS CATO-C4X-136111)
- Amphotericin B Impurity 22 (CAS CATO-C4X-184422)
- Lurasidone Impurity 79 (CAS CATO-C4X-102879)
- Sodium 2-(1-methyl-1H-1,2,4-triazol-5-yl)acetate (CAS 2137970-32-0)
- (S)-4,4-difluoro-1-glycylpyrrolidine-2-carboxylic acid (CAS 2136761-11-8)
- 3-(Dimethylamino)-2-phenylacrylonitrile (CAS 18226-50-1)
- 4-Methyl-2,3-dihydro-1H-inden-1-amine (CAS 361389-85-7)
- 3479AF 5-Chloro-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester 928653-82-1 C12H13ClN2O2 (CAS 928653-82-1)
- 1-(1-phenylethyl)piperidin-4-one (CAS 91600-21-4)
- Semaglutide impurity 248 (CAS CATO-C4X-2226248)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com