4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-iodo-6-nitrophenol CAS 1400872-24-3
| CAS No. | 1400872-24-3 |
| Molecular Formula | C12H5ClF3IN2O3 |
| Molecular Weight | 444.53 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-iodo-6-nitrophenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-iodo-6-nitrophenol (CAS 1400872-24-3), molecular formula C12H5ClF3IN2O3 and molecular weight 444.53 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-iodo-6-nitrophenol (C12H5ClF3IN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H5ClF3IN2O3 |
| Molecular Weight | 444.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 3-Chloro-6'-(2,4-dichlorophenoxy)-5-(trifluoromethyl)-[2,3'-bipyridine]-5'-carbonitrile (CAS 339011-79-9)
- 4-Chloro-N-(4-chloro-phenyl)-N-(6-chloro-4-trifluoromethyl-pyridin-2-yl)-benzamidine (CAS 1311283-67-6)
- 3-Chloro-2-[(1E)-(2,4-dichlorophenyl)(2-phenylhydrazin-1-ylidene)methyl]-5-(trifluoromethyl)pyridine (CAS 306977-42-4)
- Methyl 2-(2-(2-chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl)hydrazinyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 648427-12-7)
- 3-((2-Chloro-6-fluorobenzyl)thio)-5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazole (CAS 477331-50-3)
- Ethyl 4-(4-chloro-6-((2,4-dichlorobenzyl)amino)pyrimidin-2-yl)piperazine-1-carboxylate (CAS 1448166-05-9)
- 2-Chloro-N-(4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)thio)phenyl)nicotinamide (CAS 1024069-88-2)
- 2-({5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]pyrimidin-2-yl}sulfanyl)-1-(4-chlorophenyl)ethan-1-one (CAS 344263-13-4)
Recommended Standards
- Theliatinib (HMPL-309) (CAS 1353644-70-8)
- N-[3-[(5-Methoxy-3-indolyl)methylene]-2-oxo-5-indolinyl]-3-(1-piperidinyl)propanamide (CAS 181223-80-3)
- Vibegron (CAS 1190389-15-1)
- (2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide (CAS 945755-56-6)
- 2-Amino-7-ethyl-[1,2,4]triazolo[1,5-a]pyridine (CAS 1782328-62-4)
- 2-(7-Cyclopropyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-yl)acetic acid (CAS 1411766-66-9)
- Tetraethylammonium (trifluoromethanesulfonate) (CAS 35895-69-3)
- 2-(3-Methoxy-4-methylphenyl)propan-2-amine (CAS 1178479-16-7)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
- Ethyl 4-methyl-2-[4-(trifluoro-methyl)-phenyl]thiazole-5-carboxylate (CAS 175277-03-9)
- (2-(1,5-Dihydroxypyrrolidin-3-yl)ethyl)phosphonic acid (CAS 278778-55-5)
- 1-Bromo-3-(methoxy-d3)benzene-2,4,5,6-d4 (CAS 1109219-40-0)
- 3-(AMINOMETHYL)-N-(4-METHOXYPHENYL)ANILINE (CAS 1263284-49-6)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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