3-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol CAS 1447606-46-3
| CAS No. | 1447606-46-3 |
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1447606-46-3), molecular formula C8H5ClF4O and molecular weight 228.57 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (C8H5ClF4O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF4O |
| Molecular Weight | 228.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (2-Chloro-6-fluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 110499-66-6)
- 1-(4-Chloro-3-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1247205-10-2)
- 1-(2-Chloro-6-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1249544-27-1)
- 2-[Chloro(difluoro)methoxy]-1,3-difluoro-4-methyl-benzene (CAS 1404194-29-1)
- 1-[Chloro(difluoro)methoxy]-2,3-difluoro-4-methyl-benzene (CAS 1404194-41-7)
- (4-Chloro-3-fluoro-5-(trifluoromethyl)phenyl)methanol (CAS 1431329-65-5)
- (3-Chloro-2-fluoro-4-(trifluoromethyl)phenyl)methanol (CAS 1431329-79-1)
- 2-Chloro-4-fluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1447607-62-6)
Recommended Standards
- 1-(4-Chloro-2-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1514167-13-5)
- 2-(Chloromethyl)-1-fluoro-4-(trifluoromethoxy)benzene (CAS 1517586-69-4)
- 1-(3-Chloro-2-fluorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 1601250-20-7)
- 1-(Chloromethyl)-2-fluoro-3-(trifluoromethoxy)benzene (CAS 1373864-66-4)
- 4-(N-benzylmethylsulfonamido)benzoic acid (CAS 333357-39-4)
- 4-Chloro-N-(4-fluorophenyl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxamide (CAS 339031-72-0)
- 2-(Iodomethyl)-5-methyl-1,3,4-oxadiazole (CAS 142070-92-6)
- Methyldiphenyl(vinyl)silane (CAS 13107-13-6)
- 2-(2-Isopropoxyethyl)piperidine (CAS 1018628-43-7)
- but-3-ynyl N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]carbamate (CAS 1680212-44-5)
- (2R,3R,3aS,4S,6aS)-Hexahydro-N-methyl-2,4-methano-4H-furo[3,2-b]pyrrol-3-amine (CAS 25161-91-5)
- 1-(2-(2-(Ethyl(methyl)amino)pyridin-3-yl)piperidin-1-yl)ethanone (CAS 1352500-76-5)
- 5-(4-Chlorophenyl)-3,4-dihydro-2H-pyrrole (CAS 22217-78-3)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
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