Binimetinib Impurity N1 CAS 1415559-75-9
| CAS No. | 1415559-75-9 |
| Molecular Formula | C19H17BrF2N4O3 |
| Molecular Weight | 467.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C19H17BrF2N4O3, Binimetinib Impurity N1 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 467.26 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Binimetinib Impurity N1 (CAS 1415559-75-9) is a certified pharmaceutical impurity reference standard with the molecular formula C19H17BrF2N4O3 and a molecular weight of 467.26 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17BrF2N4O3 |
| Molecular Weight | 467.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related Binimetinib Standards
- Binimetinib Impurity 6 (CAS CATO-C4X-30506)
- Binimetinib Impurity 7 (CAS CATO-C4X-30507)
- Binimetinib Impurity 2 (CAS CATO-C4X-30502)
- Binimetinib Impurity 4 (CAS CATO-C4X-30504)
- Binimetinib-D3 (CAS CATO-C4X-30508)
- Binimetinib (CAS 606143-89-9)
- Binimetinib Amide Impurity (CAS 1604812-70-5)
- Binimetinib Impurity 3 (CAS CATO-C4X-30503)
Recommended Standards
- 4-(Furan-2-carbonyl)-3-hydroxy-5-(4-iodophenyl)-1-(3-methoxypropyl)-1H-pyrrol-2(5H)-one (CAS 609797-02-6)
- Resmetirom impurity 91 (CAS CATO-C4X-291291)
- 2-(5-(3-(4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid (CAS 1030612-90-8)
- N-(4-(((4-bromophenyl)thio)methyl)phenyl)-3,5-dichlorobenzamide (CAS 321431-77-0)
- Doxofylline Impurity 29 (CAS 97-97-2)
- Cholic Acid Impurity 84 (CAS CATO-C4X-116084)
- Warfarin Impurity N2 (CAS 15151-14-1)
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- N-Benzyl-6-chloropyrazine-2-carboxamide (CAS 1426690-33-6)
- 2-Ethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 848243-23-2)
- 2-(5-Bromopyridin-3-yl)ethan-1-amine (CAS 39741-47-4)
- 4-Chloro-2-methoxy-5-nitro-benzoic acid methyl ester (CAS 109069-75-2)
- N-(2,3-Dihydro-1H-inden-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine hydrochloride (CAS 2007916-90-5)
- Tirzepatide(sodium salt) (CAS 2023788-19-2(free base))
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