Binimetinib Impurity 4 CAS CATO-C4X-30504
| CAS No. | CATO-C4X-30504 |
| Molecular Formula | C19H17BrF2N4O4 |
| Molecular Weight | 483.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Binimetinib Impurity 4 (C19H17BrF2N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Binimetinib Impurity 4 (CAS CATO-C4X-30504, C19H17BrF2N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17BrF2N4O4 |
| Molecular Weight | 483.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 4 |
Related Binimetinib Standards
- Binimetinib Impurity 2 (CAS CATO-C4X-30502)
- Binimetinib Impurity 7 (CAS CATO-C4X-30507)
- Binimetinib Amide Impurity (CAS 1604812-70-5)
- Binimetinib Impurity N1 (CAS 1415559-75-9)
- Binimetinib Impurity 6 (CAS CATO-C4X-30506)
- Binimetinib-D3 (CAS CATO-C4X-30508)
- Binimetinib (CAS 606143-89-9)
- Binimetinib Impurity 3 (CAS CATO-C4X-30503)
Recommended Standards
- N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]-5-iodo-pentanamide (CAS 2703834-53-9)
- 3,4-Dichloro-N-{3-cyano-4-[3-(trifluoromethyl)benzenesulfinyl]phenyl}benzamide (CAS 477709-97-0)
- (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-((3-iodobenzyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol (CAS 163152-30-5)
- Domperidone Impurity 41 (CAS CATO-C4X-142041)
- Domperidone Impurity 24 (CAS 99-54-7)
- Atrasentan Impurity 77 (CAS 1058551-16-8)
- Empagliflozin Impurity 101 (CAS CATO-C4X-1065101)
- 2-(difluoromethyl)-2-methylmorpholine hydrochloride (CAS 2031269-52-8)
- (R)-1-(4-chloro-3-fluorophenyl)pentan-1-amine (CAS 1213027-89-4)
- 3-((2R,3S)-1-(tert-butoxycarbonyl)-3-((tert-butyldimethylsilyl)oxy)piperidin-2-yl)propanoic acid (CAS 2241812-35-9)
- 1-(2,3-Dimethylphenyl)-3-methylbutan-1-one (CAS 1226180-21-7)
- Letermovir Impurity 70 (CAS CATO-C4X-291570)
- 1H-Imidazole-1-ethanol, 4,5-dihydro-2-undecyl- (CAS 136-99-2)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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