Roxadustat Impurity 5 CAS 1421312-36-8
| CAS No. | 1421312-36-8 |
| Molecular Formula | C20H18N2O5 |
| Molecular Weight | 366.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Roxadustat Impurity 5 (CAS 1421312-36-8), a pharmacopoeial impurity reference standard (molecular formula C20H18N2O5, MW 366.37 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Roxadustat Impurity 5 (C20H18N2O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H18N2O5 |
| Molecular Weight | 366.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Impurity 101 (CAS CATO-C4X-2213101)
- Roxadustat Impurity 126 (CAS CATO-C4X-2213126)
- Roxadustat Impurity 74 (CAS CATO-C4X-221374)
- Roxadustat Impurity 49 (CAS CATO-C4X-221349)
- Roxadustat Impurity N5 (CAS 1509958-20-6)
- Roxadustat impurity 134 (CAS 2243807-81-8)
- Roxadustat Impurity 132 (CAS CATO-C4X-2213132)
- Roxadustat Impurity 154 (CAS CATO-C4X-2213154)
Recommended Standards
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- 6-Cyclobutoxypicolinic acid (CAS 1250298-25-9)
- [7-L-glutamic acid]Terlipressin (CAS CATO-C4X-21936)
- Ganciclovir EP Impurity I (CAS 86357-20-2)
- 5-Fluoro-3-phenylbenzoic acid (CAS 1082565-35-2)
- 2-(4-(8-Bromo-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (CAS 1624261-99-9)
- Acetyl Tetrapeptide-11 (CAS 928006-88-6)
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