Aprepitant Impurity 25 CAS 78-69-3

Purity >90%In StockPharmacopoeial Impurity Standards
CAS No.78-69-3
Molecular FormulaC10H22O
Molecular Weight158.28 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Aprepitant Impurity 25 CAS 78-69-3 chemical structure

Description

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Aprepitant Impurity 25 (CAS 78-69-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H22O and a molecular weight of 158.28 g/mol.

Owing to a hydroxyl group, an ether linkage, Aprepitant Impurity 25 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 158.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

Physical & Chemical Properties

Molecular FormulaC10H22O
Molecular Weight158.28 g/mol
Purity>90%
StorageStore at 2-8°C
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityStable under recommended storage conditions
Degree of Unsaturation (DBE)0.0
CAS Registry Year (est.)1957

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