Osimertinib Impurity N1 CAS 1421372-67-9
| CAS No. | 1421372-67-9 |
| Molecular Formula | C25H29N7O3 |
| Molecular Weight | 475.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 475.54 g/mol gives Osimertinib Impurity N1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Osimertinib Impurity N1 (CAS 1421372-67-9), a pharmacopoeial impurity reference standard (molecular formula C25H29N7O3, MW 475.54 g/mol) used for the identification and quantification of trace impurities in APIs.
Osimertinib Impurity N1 (C25H29N7O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Osimertinib Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H29N7O3 |
| Molecular Weight | 475.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 7 |
Related Osimertinib Standards
- Osimertinib Impurity 88 (CAS CATO-C4X-204588)
- Osimertinib Impurity 101 (CAS CATO-C4X-2045101)
- Osimertinib Impurity 18 (CAS CATO-C4X-204518)
- Osimertinib Impurity N3 (CAS 1421373-99-0)
- Osimertinib Impurity 10 (CAS 1421373-98-9)
- Osimertinib Impurity 30 (CAS CATO-C4X-204530)
- Osimertinib Impurity 92 (CAS CATO-C4X-204592)
- Osimertinib Impurity 41 (CAS CATO-C4X-204541)
Recommended Standards
- N-[[4-[[[4-[[tert-Butyloxycarbonyl]amino][1,1-biphenyl]-3-yl]amino]carbonyl]phenyl]methyl]carbamic Acid Methyl Ester (CAS 1013330-69-2)
- 2-(4-(Dibenzo[b,d]furan-2-yl)phenyl)-4,6-diphenyl-1,3,5-triazine (CAS 1622290-42-9)
- Methyl 2-({4-[(1E)-{[(4-fluorophenyl)methoxy]imino}methyl]-1-methyl-3-phenyl-1H-pyrazol-5-yl}sulfanyl)benzoate (CAS 321998-49-6)
- N-(1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(4-phenoxyphenyl)acetamide (CAS 1796882-73-9)
- Rimegepant Impurity 90 (CAS CATO-C4X-248790)
- Olprinone Impurity 20 (CAS CATO-C4X-204320)
- Valproate Impurity 49 (CAS 40239-27-8)
- 1,4-Dideoxy-1,4-imino-D-arabinitol Hydrochloride (CAS 100991-92-2)
- 2-(benzylamino)pentanedioic acid (CAS 911319-76-1)
- 1-[1-(4-methanesulfonylphenyl)ethyl]piperidin-4-amine (CAS 1038973-85-1)
- N-allyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine (CAS 606136-08-7)
- Pbb-No. 155 (CAS 59261-08-4)
- 4-(4-Chloro-1h-pyrazol-1-yl)-2-(isopropylamino)butanoic acid (CAS 1342084-31-4)
- Tau Peptide (275-305) (Repeat 2 Domain) trifluoroacetate salt (CAS 330456-25-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com