Osimertinib Impurity 92 CAS CATO-C4X-204592
| CAS No. | CATO-C4X-204592 |
| Molecular Formula | C27H31N7O2 |
| Molecular Weight | 485.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Osimertinib Impurity 92 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Osimertinib Impurity 92 (CAS CATO-C4X-204592, C27H31N7O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, Osimertinib Impurity 92 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 485.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Osimertinib Impurity 92 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H31N7O2 |
| Molecular Weight | 485.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 7 |
Related Osimertinib Standards
- Osimertinib Impurity N3 (CAS 1421373-99-0)
- Osimertinib Impurity 10 (CAS 1421373-98-9)
- Osimertinib Impurity 30 (CAS CATO-C4X-204530)
- Osimertinib Impurity 41 (CAS CATO-C4X-204541)
- Osimertinib Impurity N1 (CAS 1421372-67-9)
- Osimertinib Impurity 88 (CAS CATO-C4X-204588)
- Osimertinib Impurity 101 (CAS CATO-C4X-2045101)
- Osimertinib Impurity 18 (CAS CATO-C4X-204518)
Recommended Standards
- N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(4-(tert-butoxy)-4-oxobutyl)-L-cysteine (CAS 102971-73-3)
- tert-Butyl-7-[4-(4-fluorophenyl)-6-isopropyl-2-aminopyrimidin-5-yl]-(3R,5S)-isopropylidene-(E)-6-heptenoate (CAS 1448436-04-1)
- AZD-9291 Impurity 6 (CAS CATO-C4X-11276)
- (2S)-4-{[3-(tert-butoxy)-3-oxopropyl]sulfanyl}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoic acid (CAS 98441-66-8)
- Apixaban Impurity 51 (CAS CATO-C4X-108851)
- Tenofovir disoproxil Impurity 99 (CAS CATO-C4X-107699)
- Posaconazole impurity 213 (CAS CATO-C4X-1208213)
- N-(4-Chloro-3-fluorobenzyl)-[3,4'-bipyridin]-5-amine (CAS 821784-74-1)
- 3-Bromo-4,5-difluorobenzaldehyde (CAS 1143502-70-8)
- 5,7-Dioxo-4,5-dihydrothiazolo[4,5-d]pyrimidin-6(7H)-yl benzenesulfonate (CAS 18903-21-4)
- Cabazitaxel Impurity 50 (4R) (CAS CATO-C4X-111550)
- 1-(4,5,6,7-Tetrahydro-1H-indol-2-yl)ethanone (CAS 94393-93-8)
- 2-(Pyrazin-2-yl)acetohydrazide (CAS 934172-14-2)
- (Tyr?)-C-Peptide (human) (CAS 57327-90-9)
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