Osimertinib Impurity 10 CAS 1421373-98-9
| CAS No. | 1421373-98-9 |
| Molecular Formula | C27H31N7O2 |
| Molecular Weight | 485.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Osimertinib Impurity 10 (CAS 1421373-98-9, C27H31N7O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Osimertinib Impurity 10 (C27H31N7O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H31N7O2 |
| Molecular Weight | 485.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 7 |
Related Osimertinib Standards
- Osimertinib Impurity N3 (CAS 1421373-99-0)
- Osimertinib Impurity 30 (CAS CATO-C4X-204530)
- Osimertinib Impurity 92 (CAS CATO-C4X-204592)
- Osimertinib Impurity 41 (CAS CATO-C4X-204541)
- Osimertinib Impurity N1 (CAS 1421372-67-9)
- Osimertinib Impurity 88 (CAS CATO-C4X-204588)
- Osimertinib Impurity 101 (CAS CATO-C4X-2045101)
- Osimertinib Impurity 18 (CAS CATO-C4X-204518)
Recommended Standards
- AZD-9291 Impurity 6 (CAS CATO-C4X-11276)
- Ibrutinib Impurity 165 (CAS CATO-C4X-1064165)
- Ibrutinib Impurity 164 (CAS CATO-C4X-1064164)
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- Tofacitinib Nitroso Impurity 191 (CAS CATO-C4X-1079191)
- Urapidil Impurity 28 (CAS 16015-70-6)
- Ticagrelor Impurity 191 (CAS CATO-C4X-1093191)
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- 2-Amino-6-(aminomethyl)-3-(difluoromethyl)isonicotinaldehyde (CAS 1806827-98-4)
- 4-Cyano-3-(difluoromethyl)-5-fluoropyridine-2-sulfonyl chloride (CAS 1806876-12-9)
- Ethyl 2-(3-tosylureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (CAS 799820-56-7)
- Semaglutide Impurity 164 (CAS CATO-C4X-2226164)
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