Tenofovir Alafenamide Impurity 3 CAS 1422343-76-7
| CAS No. | 1422343-76-7 |
| Molecular Formula | C21H29N6O5P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tenofovir Alafenamide Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Tenofovir Alafenamide Impurity 3 (CAS 1422343-76-7), a pharmacopoeial impurity reference standard (molecular formula C21H29N6O5PC4H4O4, MW 592.55 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tenofovir Alafenamide Impurity 3 (C21H29N6O5PC4H4O4) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H29N6O5P C4H4O4 |
| Molecular Weight | 592.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- Trelagliptin Impurity 19 (CAS CATO-C4X-104619)
- Carfilzomib Impurity 2 (CAS 247068-84-4)
- Indoxacarb Impurity 6 (CAS CATO-C4X-24846)
- 2-Azaspiro[4.5]Decan-4-ol (CAS 1779940-17-8)
- N-Ethyl-ethanamine- (CAS 251901-52-7)
- 3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS 1172057-73-6)
- 3-[(1,2-Benzisothiazol-3-ylcarbonyl)amino]-4-methylbenzoic acid (CAS 950360-17-5)
- 2-((4-Bromo-1-methyl-1H-pyrazol-5-yl)methylene)malononitrile (CAS 1005672-95-6)
- 1-(6-Ethylpyridin-3-yl)ethan-1-one (CAS 1211536-35-4)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
Why CATO?
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