Tenofovir alafenamide Impurity 79 CAS 102-10-3
| CAS No. | 102-10-3 |
| Molecular Formula | C12H11O3P |
| Molecular Weight | 234.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Tenofovir alafenamide Impurity 79 (CAS 102-10-3), a pharmacopoeial impurity reference standard (molecular formula C12H11O3P, MW 234.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C12H11O3P, Tenofovir alafenamide Impurity 79 contains a phosphonate group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 234.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11O3P |
| Molecular Weight | 234.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Tenofovir Standards
- Tenofovir alafenamide impurity 79 (CAS 126771-33-3)
- Tenofovir alafenamide impurity 80 (CAS 126771-36-6)
- Tenofovir alafenamide impurity 82 (CAS 126771-32-2)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
- Tenofovir disoproxil Impurity 42 (CAS 1878175-82-6)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir disoproxil Impurity 143 (CAS CATO-C4X-1076143)
Recommended Standards
- 4-(Pentafluoro-λ6-sulfanyl)benzene-1,2-diamine (CAS 663179-59-7)
- Diphenyl Phosphite (CAS 4712-55-4)
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- Isopropyl Citrate (mixture) (CAS 101396-15-0)
- Labetalol Impurity 58 (CAS CATO-C4X-246658)
- Ibrutinib Impurity 155 (CAS CATO-C4X-1064155)
- Biotin Impurity 38 (CAS CATO-C4X-156338)
- 4-Methoxy-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one (CAS 2088451-36-7)
- (+/-)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane (CAS 257641-01-3)
- (3-Chlorophenyl)(3-(thiomorpholinomethyl)phenyl)methanone (CAS 898763-03-6)
- 1,4-Dimethoxy-2-(prop-1-en-2-yl)benzene (CAS 72667-91-5)
- 3-(Bromomethyl)-5-(trifluoromethyl)-1H-indole (CAS 1823362-26-0)
- 7-Fluorobenzo[d]oxazol-5-amine (CAS 1268154-08-0)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com