Rosuvastatin (3R,5R)-Lactone CAS 1422954-11-7
| CAS No. | 1422954-11-7 |
| Molecular Formula | C22H26FN3O5S |
| Molecular Weight | 463.52 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Rosuvastatin (3R,5R)-Lactone (CAS 1422954-11-7), molecular formula C22H26FN3O5S and molecular weight 463.52 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, Rosuvastatin (3R,5R)-Lactone is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 463.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C22H26FN3O5S |
| Molecular Weight | 463.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Rosuvastatin Standards
- Rosuvastatin Impurity 74 (CAS 615263-62-2)
- Rosuvastatin (2S,4S)-Lactone (CAS 1809092-87-2)
- (Z)-Rosuvastatin Lactone (CAS CATO-C4X-1169133)
- Rosuvastatin EP Impurity N (CAS 2290571-51-4)
- Rosuvastatin EP Impurity K (CAS 1422954-12-8)
- Rosuvastatin Impurity 256 (CAS 1422954-13-9)
- Rosuvastatin (2R)-Lactone (CAS CATO-C4X-116941)
- Rosuvastatin EP Impurity D (CAS 503610-43-3)
Recommended Standards
- Spirotetramat-enol-glucoside (CAS 1172614-86-6)
- Fmoc-4-phenyl-D-Phe-OH (CAS 205526-38-1)
- Venlafaxine Impurity 13 (CAS CATO-C4X-143413)
- Fmoc-4-phenyl-Phe-OH (CAS 199110-64-0)
- 4-Fluoro-3-(furan-3-yl)benzaldehyde (CAS 1343383-69-6)
- (3aS,6aR)-3,3a,6,6a-Tetrahydro-2H-cyclopenta[b]furan-2-one (CAS 54483-22-6)
- 2-Chloro-3-iodoquinoxaline (CAS 258506-64-8)
- 4-Chloro-2-(3-methoxyphenyl)-5-(methylamino)pyridazin-3(2H)-one (CAS 84607-75-0)
- Methyl 4-(benzyloxy)-3-fluorobenzoate (CAS 2379322-19-5)
- 2-(2-(Methylsulfonyl)phenoxy)acetic acid (CAS 1017782-54-5)
- N-(3-Bromo-5-ethylphenyl)acetamide (CAS 123158-67-8)
- Methyl 3-chloro-5-methoxypicolinate (CAS 128073-14-3)
- 4-Bromoisothiazol-3(2H)-one (CAS 25629-52-1)
- Palmitoyl hexapeptide-6 (CAS 891498-01-4)
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