Vonoprazan Impurity 216 CAS 1428932-17-5
| CAS No. | 1428932-17-5 |
| Molecular Formula | C11H10FN |
| Molecular Weight | 175.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Vonoprazan Impurity 216 (CAS 1428932-17-5, C11H10FN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vonoprazan Impurity 216 (C11H10FN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C11H10FN |
| Molecular Weight | 175.20 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Vonoprazan Standards
- Vonoprazan Impuirty 86 (CAS 5402-21-1)
- Vonoprazan Impurity 289 (CAS CATO-C4X-1020289)
- Vonoprazan Impurity 192(Mixture of Z and E Isomers) (CAS CATO-C4X-1020192)
- Vonoprazan Impurity 200 (CAS CATO-C4X-1020200)
- Vonoprazan Impurity 112 (CAS 881673-95-6)
- Vonoprazan Impurity 188 (CAS 111480-82-1)
- Vonoprazan Impurity 189 (CAS CATO-C4X-1020189)
- Vonoprazan Impurity 54 (CAS 1421640-34-7)
Recommended Standards
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- Sitafloxacin Impurity 43 (CAS 127199-16-0)
- rel-Methyl 2-((3R,5R)-5-fluoropiperidin-3-yl)acetate (CAS 2761952-53-6)
- 5-(2-Thienyl)-1H-pyrazole-4-carbonitrile (CAS 1008428-30-5)
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- Atomoxetine Impurity 9 (CAS 128036-32-8)
- N-nitroso-berotralstat (CAS CATO-C4X-29791)
- 6-Bromo-2-(4-fluorophenyl)-3-(piperazin-1-ylmethyl)imidazo[1,2-a]pyridine (CAS 727977-41-5)
- 5-Chloro-2-fluoronicotinonitrile (CAS 1807007-21-1)
- Ethyl 2-(5-chloro-1H-1,2,4-triazol-1-yl)propanoate (CAS 1823829-53-3)
- Sodium 2-hydroxy-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2-sulfonate (CAS 102226-50-6)
- 1-(4-Bromo-2-chlorobenzyl)piperidin-4-ol (CAS 1057269-96-1)
- 1-Methyl-3-(4-piperidyl)imidazolidin-2-one (CAS 52211-04-8)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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