Letrozole Impurity 9 CAS 143030-54-0
| CAS No. | 143030-54-0 |
| Molecular Formula | C16H11BrN4 |
| Molecular Weight | 339.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Letrozole Impurity 9 (C16H11BrN4) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Letrozole Impurity 9 (CAS 143030-54-0) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11BrN4 and a molecular weight of 339.19 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Letrozole Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H11BrN4 |
| Molecular Weight | 339.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Letrozole Standards
- Letrozole Impurity 20 (CAS CATO-C4X-182920)
- Letrozole Impurity 7 (CAS 1644566-39-1)
- Letrozole Impurity 8 (CAS 2170106-13-3)
- Letrozole EP Impurity B (CAS 113402-31-6)
- Letrozole Impurity 21 (CAS CATO-C4X-182921)
- Letrozole Impurity 12 (CAS CATO-C4X-182912)
- Letrozole Impurity 13 (CAS CATO-C4X-182913)
- Letrozole Impurity 10 (CAS CATO-C4X-182910)
Recommended Standards
- Trimethoprim EP Impurity F (CAS 16285-82-8)
- Brodimoprim (CAS 56518-41-3)
- Phenyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 756520-47-5)
- Methyl 8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxylate (CAS 1189815-76-6)
- Ilaprazole Impurity 145 (CAS 67382-06-3)
- Progesterone Impurity 61 (CAS CATO-C4X-150261)
- Cholecalciferol Impurity 19 (CAS CATO-C4X-158619)
- ({2,4-dichloropyrrolo[2,1-f][1,2,4]triazin-7-yl}methyl)(methyl)amine (CAS 2092154-21-5)
- 1-(3,5-Difluorophenyl)-N-methylmethanamine (CAS 90390-28-6)
- 4-[(4-Bromophenyl)sulfanyl]-2-{[(3,4-dichlorophenyl)methyl]sulfanyl}-5-methoxypyrimidine (CAS 339276-02-7)
- 4-(2,6,6-Trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (CAS 497061-30-0)
- n-(5-Amino-4-(benzo[d]thiazol-2-yl)-3-oxo-2,3-dihydro-1h-pyrrol-1-yl)thiophene-2-carboxamide (CAS 847783-78-2)
- 4-Methyl-2-(trifluoromethyl)pyridine (CAS 1620-79-7)
- Semaglutide impurity 29 (CAS 1188328-22-4)
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