Letrozole Impurity 12 CAS CATO-C4X-182912
| CAS No. | CATO-C4X-182912 |
| Molecular Formula | C17H11N5O2 |
| Molecular Weight | 317.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Letrozole Impurity 12 (CAS CATO-C4X-182912, C17H11N5O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Letrozole Impurity 12 (C17H11N5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Letrozole Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C17H11N5O2 |
| Molecular Weight | 317.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Letrozole Standards
- Letrozole Impurity 13 (CAS CATO-C4X-182913)
- Letrozole Impurity 21 (CAS CATO-C4X-182921)
- Letrozole EP Impurity B (CAS 113402-31-6)
- Letrozole Impurity 8 (CAS 2170106-13-3)
- Letrozole Impurity 7 (CAS 1644566-39-1)
- Letrozole Impurity 10 (CAS CATO-C4X-182910)
- Letrozole Impurity 31 (CAS CATO-C4X-182931)
- Letrozole Impurity 3 (CAS CATO-C4X-18293)
Recommended Standards
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- Entacapone impurity 19 (CAS CATO-C4X-162919)
- Nilotinib EP Impurity B (CAS 18595-18-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com