Tacrolimus EP Impurity H CAS 143210-33-7
| CAS No. | 143210-33-7 |
| Molecular Formula | C43H69NO11 |
| Molecular Weight | 776.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Tacrolimus EP Impurity H (C43H69NO11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Tacrolimus EP Impurity H (CAS 143210-33-7), a pharmacopoeial impurity reference standard (molecular formula C43H69NO11, MW 776.01 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tacrolimus EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C43H69NO11 |
| Molecular Weight | 776.01 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus Impurity 2 (Discontinue) (CAS CATO-C4X-13002)
- Tacrolimus Impurity 31 (CAS 123719-19-7)
- Tacrolimus impurity 48 (CAS CATO-C4X-130048)
- Tacrolimus impurity 72 (CAS CATO-C4X-130072)
- Tacrolimus Impurity 52 (CAS CATO-C4X-130052)
- Tacrolimus Impurity 3 (CAS CATO-C4X-13003)
- Tacrolimus EP Impurity I (CAS 104987-16-8)
- Tacrolimus Impurity 54 (CAS CATO-C4X-130054)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com