Tacrolimus impurity 48 CAS CATO-C4X-130048
| CAS No. | CATO-C4X-130048 |
| Molecular Formula | C43H69NO11 |
| Molecular Weight | 776.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Tacrolimus impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Tacrolimus impurity 48 (CAS CATO-C4X-130048, C43H69NO11) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Tacrolimus impurity 48 (C43H69NO11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C43H69NO11 |
| Molecular Weight | 776.01 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus EP Impurity H (CAS 143210-33-7)
- Tacrolimus Impurity 2 (Discontinue) (CAS CATO-C4X-13002)
- Tacrolimus Impurity 31 (CAS 123719-19-7)
- Tacrolimus impurity 72 (CAS CATO-C4X-130072)
- Tacrolimus Impurity 52 (CAS CATO-C4X-130052)
- Tacrolimus Impurity 3 (CAS CATO-C4X-13003)
- Tacrolimus EP Impurity I (CAS 104987-16-8)
- Tacrolimus Impurity 54 (CAS CATO-C4X-130054)
Recommended Standards
- Pimecrolimus Impurity 22 (CAS 137712-89-1)
- Cobicistat (CAS 1004316-88-4)
- Cobicistat Impurity 3 (CAS 1051463-82-1)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
- Lansoprazole Impurity 14 (CAS 112525-75-4)
- Vonoprazan Impurity 240 (CAS CATO-C4X-1020240)
- Lenvatinib Impurity 112 (CAS 82121-05-9)
- 5-Methoxy-7-methylbenzofuran (CAS 1388059-31-1)
- 3-Cyclopropoxy-5-nitropyridin-4-amine (CAS 1243401-79-7)
- 2-Cyclopropoxy-4-(trifluoromethyl)benzoic acid (CAS 1243473-18-8)
- 2-Chloro-5-(3,5-dimethoxybenzoyl)pyridine (CAS 1187169-82-9)
- 1-(2-(4-Phenylpiperazin-1-yl)ethyl)isoquinoline (CAS 126921-46-8)
- (3Z)-5-bromo-1H-indole-2,3-dione 3-oxime (CAS 49675-78-7)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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