Pregabalin Impurity 66 CAS 143420-53-5
| CAS No. | 143420-53-5 |
| Molecular Formula | C8H12N2O |
| Molecular Weight | 152.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Pregabalin Impurity 66 (CAS 143420-53-5, C8H12N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H12N2O, Pregabalin Impurity 66 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 152.19 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Pregabalin Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N2O |
| Molecular Weight | 152.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Nitrogen Atoms | 2 |
Related Pregabalin Standards
- Pregabalin EP Impurity C(Glycopyrronium Bromide EP Impurity C) (CAS 90-64-2)
- Pregabalin Impurity 65 (CAS 869-02-3)
- Pregabalin Impurity 63 (CAS 7214-61-1)
- Pregabalin Impurity 150 (CAS 51840-50-7)
- Pregabalin Impurity 151 (CAS 57422-87-4)
- Pregabalin Impurity 115 (CAS CATO-C4X-1312115)
- Pregabalin Impurity N48 (CAS 35158-25-9)
- pregabalin Impurity 36 (CAS 181289-16-7)
Recommended Standards
- Piracetam Impurity 12 (CAS 7060-52-8)
- Umeclidinium impurity 23 (CAS 622-08-2)
- Rivaroxaban Impurity 125 (CAS 19298-14-7)
- Metoprolol EP Impurity B (CAS 56718-71-9)
- Erlotinib Impurity 61 (CAS 20825-87-0)
- Loxoprofen Impurity 47 (CAS CATO-C4X-148847)
- Riociguat Impurity N13 (CAS 6017-21-6)
- 5-Chloro-7-methylpyrazolo[1,5-a]pyridine (CAS 1427374-70-6)
- 2-(2-Amino-5-iodophenyl)acetic acid (CAS 1261810-98-3)
- 3-Cyclopropoxy-4-isopropyl-2-methylpyridine (CAS 1243456-61-2)
- (R)-1-(3-bromo-5-methylphenyl)but-3-en-1-amine (CAS 1270101-73-9)
- 2-Hydroxyquinoline-6-sulfonyl Chloride (CAS 569340-07-4)
- 2-(6,7-Dihydrothieno[3,2-c]pyridin-5(4h)-yl)-6-fluorobenzonitrile (CAS 1241255-45-7)
- His-Aib-Semaglutide (CAS CATO-C4X-2226220)
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