Metoprolol EP Impurity B CAS 56718-71-9

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.56718-71-9
Molecular FormulaC9H12O2
Molecular Weight152.19 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Metoprolol EP Impurity B CAS 56718-71-9 chemical structure

Description

As a process- or degradation-related impurity, Metoprolol EP Impurity B (CAS 56718-71-9, C9H12O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Metoprolol EP Impurity B (C9H12O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

As a certified reference material (CRM), Metoprolol EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC9H12O2
Molecular Weight152.19 g/mol
AppearanceOff-white to pale yellow crystalline powder
Purity>95%
StorageStore at 2-8°C
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1973

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