2-Chloro-5-(trifluoromethyl)thiophene CAS 143469-21-0
| CAS No. | 143469-21-0 |
| Molecular Formula | C5H2ClF3S |
| Molecular Weight | 186.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 186.58 g/mol gives 2-Chloro-5-(trifluoromethyl)thiophene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-Chloro-5-(trifluoromethyl)thiophene (CAS 143469-21-0), a certified reference material (molecular formula C5H2ClF3S, MW 186.58 g/mol) for analytical method development and quality control.
Structurally, 2-Chloro-5-(trifluoromethyl)thiophene (C5H2ClF3S) contains sulfur-containing functionality, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 186.58 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-5-(trifluoromethyl)thiophene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H2ClF3S |
| Molecular Weight | 186.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-chloro-2-(trifluoromethyl)thiophene (CAS 143469-23-2)
- Ethyl 4-chloro-3,3-difluorobutanoate (CAS 2138411-53-5)
- 4-Chloro-2-(hydroxymethyl)benzoic acid (CAS 100448-59-7)
- Methyl 2-Chloro-4-hydroxybenzoate (CAS 104253-44-3)
- 3-Chloro-2,4-dihydroxy-6-methylbenzaldehyde (CAS 106325-72-8)
- 2-Chloro-4-(hydroxymethyl)benzoic acid (CAS 1071989-48-4)
- Methyl 2-chloro-3-hydroxybenzoate (CAS 1125632-11-2)
- 2-Chloro-6-hydroxy-4-methoxybenzaldehyde (CAS 116475-68-4)
Recommended Standards
- Diethyl (chloromethyl)phosphonate (CAS 3167-63-3)
- 3-Chloro-4-fluoro-1H-indazol-6-ol (CAS 887569-25-7)
- tert-Butyl chlorodifluoroacetate (CAS 167308-43-2)
- 7-Chloro-5-fluoroisobenzofuran-1(3H)-one (CAS 1823931-26-5)
- 1-(3-Bromophenyl)-2-phenylethan-1-one (CAS 40396-53-0)
- 6-Methyl-2-(trifluoromethyl)quinazolin-4(1H)-one (CAS 50419-66-4)
- 1143461-61-3 2-Bromo-5-(4-fluorophenyl)-1-pentene MFCD11915894 (CAS 1143461-61-3)
- Propyl 2-amino-5-hydroxybenzoate (CAS 150542-22-6)
- (1R,2R)-2-aminocyclopropan-1-ol (CAS 1392309-34-0)
- 5-Ethyl-2-(4-fluorophenyl)-5-(methoxycarbonyl)-1-methyl-3-pyrrolidinecarboxylic acid (CAS 1212422-15-5)
- 5-(3-Methoxybenzoyl)furan-2-carboxylic acid (CAS 1399662-84-0)
- 2-Chloro-N-(2-chlorobenzyl)acetamide (CAS 70289-13-3)
- (3,4-Dichlorophenyl)(2-(piperidin-1-ylmethyl)phenyl)methanone (CAS 898773-71-2)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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