3-chloro-2-(trifluoromethyl)thiophene CAS 143469-23-2
| CAS No. | 143469-23-2 |
| Molecular Formula | C5H2ClF3S |
| Molecular Weight | 186.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 186.58 g/mol gives 3-chloro-2-(trifluoromethyl)thiophene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-chloro-2-(trifluoromethyl)thiophene (CAS 143469-23-2), molecular formula C5H2ClF3S and molecular weight 186.58 g/mol, is a CATO reference standard with documented purity and traceability.
3-chloro-2-(trifluoromethyl)thiophene (C5H2ClF3S) contains sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2ClF3S |
| Molecular Weight | 186.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related chloro Standards
- 2-Chloro-5-(trifluoromethyl)thiophene (CAS 143469-21-0)
- Ethyl 4-chloro-3,3-difluorobutanoate (CAS 2138411-53-5)
- 4-Chloro-2-(hydroxymethyl)benzoic acid (CAS 100448-59-7)
- Methyl 2-Chloro-4-hydroxybenzoate (CAS 104253-44-3)
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- 2-Chloro-6-hydroxy-4-methoxybenzaldehyde (CAS 116475-68-4)
Recommended Standards
- tert-Butyl chlorodifluoroacetate (CAS 167308-43-2)
- Diethyl (chloromethyl)phosphonate (CAS 3167-63-3)
- 3-Chloro-4-fluoro-1H-indazol-6-ol (CAS 887569-25-7)
- 7-Chloro-5-fluoroisobenzofuran-1(3H)-one (CAS 1823931-26-5)
- (3-Bromo-5-chloro-4-fluorophenyl)dimethylphosphine oxide (CAS 2759950-74-6)
- Methyl 6-carbamimidoylnicotinate hydrochloride (CAS 1179361-48-8)
- 1-(5-Methyl-1,3,4-oxadiazol-2-yl)cyclopropan-1-amine hydrochloride (CAS 1864016-24-9)
- (S)-2-Amino-N-isopropyl-N-(1-methyl-piperidin-4-yl)-propionamide (CAS 1354028-55-9)
- Ethyl 4-(dimethylamino)-8-methoxy-6-methylquinoline-3-carboxylate (CAS 1315346-83-8)
- Methyl 3-acetamido-5-(chloromethyl)benzoate (CAS 1393561-80-2)
- 1-(Benzyloxy)-2-methylpropan-2-ol (CAS 91968-72-8)
- 5,4'-Dihydroxy-7,3'-dimethoxyisoflavone (CAS 104668-88-4)
- Methyl 5-nitro-2-oxo-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-1'-carboxylate (CAS 1005261-77-7)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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