Emtricitabine Impurity N1 CAS 143790-05-0
| CAS No. | 143790-05-0 |
| Molecular Formula | C8H9FN2O4S |
| Molecular Weight | 248.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Emtricitabine Impurity N1 (CAS 143790-05-0, C8H9FN2O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C8H9FN2O4S, Emtricitabine Impurity N1 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 248.23 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Emtricitabine Impurity N1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9FN2O4S |
| Molecular Weight | 248.23 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Emtricitabine Standards
- Emtricitabine Impurity 12 Sodium salt (CAS 127087-58-5)
- 5-epi-Emtricitabine Hydrochloride (CAS 483299-09-8)
- Emtricitabine Impurity 11 (CAS 145281-92-1)
- Emtricitabine trans-Cyclic Impurity (CAS CATO-C4X-123213)
- Emtricitabine cis-Cyclic Impurity (CAS CATO-C4X-123214)
- Emtricitabine Impurity 21 (CAS 145986-11-4)
- Emtricitabine Cyclic Impurity 40 (CAS CATO-C4X-123240)
- Emtricitabine Diastereomer (RS ISOMER ) (CAS 143491-54-7)
Recommended Standards
- 5-(3,4-Dimethoxyphenyl)furan-2-carboxylic Acid (CAS 1432061-01-2)
- 3,3'-Diamino-4,4'-difluorobenzophenone (CAS 148209-29-4)
- (E)-2-(3-(3-Methoxyphenyl)allylidene)malonicacid (CAS 14160-39-5)
- Ethyl 7-Nitroindole-3-acetate (CAS 1496-80-6)
- Opicapone impurity 37 (CAS CATO-C4X-240437)
- Dexamethasone Impurity 103 (CAS CATO-C4X-1165103)
- Dalilesen impurity 47 (CAS CATO-C4X-301047)
- 3-((2,2,2-Trifluoroethyl)amino)phenol (CAS 68545-83-5)
- 4-amino-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde (CAS 885272-36-6)
- 6-Oxo-2-(4-(3-(trifluoromethyl)phenoxy)phenyl)-1,4,5,6-tetrahydropyridine-3-carbonitrile (CAS 478081-40-2)
- Rel-(1R,2S)-1,2-dibromocyclohexane (CAS 19246-38-9)
- 2-(4-(Trifluoromethoxy)phenyl)pyrimidine-5-methanol (CAS 1257426-65-5)
- (1-Oxyl-2,2,3,5,5-pentamethyl-∆3-pyrroline-3-methyl) Methanethiosulfonate (CAS 339072-96-7)
- Semaglutide Impurity 165 (CAS CATO-C4X-2226165)
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