Emtricitabine cis-Cyclic Impurity CAS CATO-C4X-123214
| CAS No. | CATO-C4X-123214 |
| Molecular Formula | C8H9FN2O4S |
| Molecular Weight | 248.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Emtricitabine cis-Cyclic Impurity (CAS CATO-C4X-123214) is a certified pharmaceutical impurity reference standard with the molecular formula C8H9FN2O4S and a molecular weight of 248.23 g/mol.
The molecular framework of Emtricitabine cis-Cyclic Impurity (C8H9FN2O4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9FN2O4S |
| Molecular Weight | 248.23 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Emtricitabine Standards
- Emtricitabine Impurity 12 Sodium salt (CAS 127087-58-5)
- Emtricitabine Impurity N1 (CAS 143790-05-0)
- 5-epi-Emtricitabine Hydrochloride (CAS 483299-09-8)
- Emtricitabine Impurity 11 (CAS 145281-92-1)
- Emtricitabine trans-Cyclic Impurity (CAS CATO-C4X-123213)
- Emtricitabine Impurity 21 (CAS 145986-11-4)
- Emtricitabine Cyclic Impurity 40 (CAS CATO-C4X-123240)
- Emtricitabine Diastereomer (RS ISOMER ) (CAS 143491-54-7)
Recommended Standards
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- Nilotinib Impurity 50 (CAS CATO-C4X-125650)
- Enzalutamide Impurity N1 (CAS 2227589-23-1)
- Ibrutinib Impurity 63 (CAS CATO-C4X-106463)
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