5-Chloro-2-(pyridin-3-yl)-1,6-naphthyridine CAS 1443286-75-6
| CAS No. | 1443286-75-6 |
| Molecular Formula | C13H8ClN3 |
| Molecular Weight | 241.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-2-(pyridin-3-yl)-1,6-naphthyridine.
5-Chloro-2-(pyridin-3-yl)-1,6-naphthyridine (CAS 1443286-75-6), molecular formula C13H8ClN3 and molecular weight 241.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-2-(pyridin-3-yl)-1,6-naphthyridine (C13H8ClN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8ClN3 |
| Molecular Weight | 241.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 1-Chloro-3-(pyridin-4-yl)-2,6-naphthyridine (CAS 1071017-49-6)
- 1-Chloro-3-(pyridin-4-yl)-2,7-naphthyridine (CAS 1211593-56-4)
- 8-Chloro-6-(pyridin-4-yl)-1,7-naphthyridine (CAS 1211595-29-7)
- 2-Chloro-3-(2-pyridinyl)quinoxaline (CAS 7755-94-4)
- 2-chloro-6-(trifluoromethyl)quinoline (CAS 78060-56-7)
- 4-Chloro-2-(3-pyridyl)quinazoline (CAS 98296-25-4)
- 4-chloro-2-(pyridin-2-yl)quinazoline (CAS 91748-47-9)
- 4-Chloro-2-(pyridin-4-yl)quinazoline (CAS 6484-27-1)
Recommended Standards
- Pyrido[1,2-a]benzimidazole-4-carbonitrile, 1-chloro-3-methyl- (CAS 121105-78-0)
- Lornoxicam Impurity N1 (CAS 1017791-22-8)
- Palbociclib Impurity 197 (CAS 1314997-73-3)
- 4-Chloro-2-phenylpyrido[2,3-d]pyrimidine (CAS 41803-67-2)
- Methyl (4-hydroxy-1,2-dihydropyrimido-[1,2-a]benzimidazol-2-yl)acetate (CAS 1306739-45-6)
- 4-[2-(3-Methyl-4-nitrophenoxy)ethyl]piperidinehydrochloride (CAS 1220029-89-9)
- tert-Butyl ((6-(4-ethylpiperazin-1-yl)-2-methylpyridin-3-yl)methyl)carbamate (CAS 1355196-82-5)
- 1H-Pyrazolo[3,4-d]pyrimidin-3-amine (CAS 875215-47-7)
- 2-(Thiazol-2-ylmethylene)malononitrile (CAS 771565-96-9)
- (3-Chloro-2,4-difluorophenyl)boronic acid (CAS 1310384-18-9)
- (Cis-2-amino-2-methylcyclohexyl)methanol (CAS 34199-38-7)
- 6-(tert-Butyl)naphthalene-2,3-dicarbonitrile (CAS 32703-82-5)
- N1-(4-chloro-3-nitrophenyl)-4-(trifluoromethyl)benzamide (CAS 680215-08-1)
- KALA Amphipathic Peptide (CAS 187987-64-0)
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