2-Hydroxy-5-iodo-3-(trifluoromethyl)benzoic acid CAS 1445995-72-1
| CAS No. | 1445995-72-1 |
| Molecular Formula | C8H4F3IO3 |
| Molecular Weight | 332.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Hydroxy-5-iodo-3-(trifluoromethyl)benzoic acid (CAS 1445995-72-1), molecular formula C8H4F3IO3 and molecular weight 332.02 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Hydroxy-5-iodo-3-(trifluoromethyl)benzoic acid (C8H4F3IO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Hydroxy-5-iodo-3-(trifluoromethyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F3IO3 |
| Molecular Weight | 332.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/I-containing |
Related Hydroxy Standards
- 2-Hydroxy-3-iodo-5-(trifluoromethoxy)benzaldehyde (CAS 775330-11-5)
- 4-Hydroxy-N-(3-(4,4,5-trimethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine-1-carboxamide (CAS 1704081-94-6)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (5-(4-ethylphenyl)thiophen-2-yl)boronate (CAS 1402227-36-4)
- 7-Hydroxy-N-(3-(trifluoromethyl)-phenyl)quinoline-4-carboxamide (CAS 1624261-38-6)
- 2-Hydroxy-N-(3-(trifluoromethyl)-phenyl)quinoline-5-carboxamide (CAS 1624262-32-3)
- Methyl 4-hydroxy-1-((3-(trifluoromethyl)phenyl)carbamoyl)pyrrolidine-2-carboxylate (CAS 318247-30-2)
- 1-Hydroxy-2,3,4,7-tetramethoxyxanthone (CAS 14103-09-4)
- 6-Hydroxy-1,2,3,7-tetramethoxy-9H-xanthen-9-one (CAS 64756-87-2)
Recommended Standards
- (2-Bromophenyl)(3,5-dichlorophenyl)methanol (CAS 1443312-93-3)
- 2-(Benzyloxy)-5-bromo-1,3-dichlorobenzene (CAS 155891-94-4)
- 1-((2-Bromobenzyl)oxy)-2,3-dichlorobenzene (CAS 1309934-02-8)
- 2-((4-Bromobenzyl)oxy)-1,4-dichlorobenzene (CAS 854259-98-6)
- 2-(4-Methoxyphenyl)-1-tosyl-1H-pyrrole (CAS 637354-46-2)
- 6-Bromo-4H-pyrazolo[4,3-b]pyridine (CAS 1934875-63-4)
- (2E)-3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(pyridin-2-yl)prop-2-en-1-one (CAS 477708-82-0)
- 2-Methyl-5-nitrobenzimidamide (CAS 1249227-02-8)
- 1142211-61-7 9432AC C22H25N3O4 [{2-[4-(4-Acetylphenyl)piperazin-1-yl]-2-oxoethyl}(phenyl)amino]acetic acid (CAS 1142211-61-7)
- Spiro[2.4]Heptan-1-amine hydrochloride (CAS 17202-53-8)
- 1,2,3-Trifluoro-5-(2-methylallyl)benzene (CAS 951892-93-6)
- Methyl 7-(trifluoromethyl)-5,6-dihydrobenzo-[h]pyrazolo[5,1-b]quinazoline-10-carboxylate (CAS 313389-78-5)
- 2-Amino-1-isopropylbenzimidazole (CAS 90871-47-9)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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