Simvastatin EP Impurity G CAS 1449248-72-9
| CAS No. | 1449248-72-9 |
| Molecular Formula | C25H36O5 |
| Molecular Weight | 416.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Simvastatin EP Impurity G is closely related to a flavonoid core, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Simvastatin EP Impurity G (CAS 1449248-72-9), a pharmacopoeial impurity reference standard (molecular formula C25H36O5, MW 416.55 g/mol) used for the identification and quantification of trace impurities in APIs.
Simvastatin EP Impurity G (C25H36O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Simvastatin EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H36O5 |
| Molecular Weight | 416.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
Related Simvastatin Standards
- Simvastatin Impurity I (CAS 121624-18-8)
- Simvastatin (CAS 79902-63-9)
- Simvastatin EP Impurity K (CAS CATO-C4X-119913)
- Simvastatin Impurity 26 (CAS CATO-C4X-119926)
- Simvastatin Impurity 27 (CAS 132487-01-5)
- Simvastatin impurity 30 (CAS 92083-03-9)
- Simvastatin D3 (CAS 1002347-61-6)
- Simvastatin-d6 (CAS 1002347-71-8)
Recommended Standards
- 482-53-1 4H,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)- 4H,2-b:3,4-b']dipyran-4-one, 5-hydroxy-3-(p-hydroxyphenyl)-8,8-dimethyl-6-(3-methyl-2-butenyl)- NSC-21565 NSC21565 OSAJIN (CAS 482-53-1)
- Hydrocortisone Impurity 69 (CAS 2905373-61-5)
- Manoalide (CAS 75088-80-1)
- Progesterone Impurity 93 (CAS CATO-C4X-150293)
- Ambroxol Maillard Lactose Impurity 6(Ambroxol Impurity 75) (CAS CATO-C4X-108575)
- Flunarizine EP Impurity B DiHCl (CAS 27064-96-6)
- Naloxone Impurity 22 (CAS CATO-C4X-149322)
- 4-Pyrrolidin-2-ylpyrimidine hydrochloride (CAS 108831-49-8)
- cis-3-Methyl-4-(phenylamino)-1-(phenylmethyl)-4-piperidinecarboxamide (CAS 147292-26-0)
- [3-(4-Amino-phenyl)-isoxazol-5-yl]-methanol (CAS 885273-66-5)
- 3-(Aminomethyl)-5-(trifluoromethyl)pyrazole (CAS 1254717-53-7)
- 3,4-Dimethylphenethylamine 2-(3,4-dimethylphenyl)ethan-1-amine 2-(3,4-dimethylphenyl)ethanamine 17283-14-6 (CAS 17283-14-6)
- 1-(3-((2-Aminoethyl)(isopropyl)amino)pyrrolidin-1-yl)ethanone (CAS 1353970-18-9)
- SV40 Nuclear Transport Signal Peptide Analog (CAS 104914-40-1)
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