Progesterone EP Impurity B CAS 145-14-2
| CAS No. | 145-14-2 |
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Progesterone EP Impurity B (CAS 145-14-2), a pharmacopoeial impurity reference standard (molecular formula C21H32O2, MW 316.48 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Progesterone EP Impurity B (C21H32O2) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Progesterone EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H32O2 |
| Molecular Weight | 316.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Progesterone Standards
- Progesterone Impurity N10 (CAS 566-61-0)
- Progesterone EP Impurity C (CAS 145-15-3)
- Progesterone Impurity 57 (CAS 20283-95-8)
- Progesterone Impurity 26 (CAS 13611-97-7)
- Progesterone (CAS 57-83-0)
- Progesterone EP Impurity M (17-alpha-Progesterone) (CAS 2000-66-0)
- 16-delta Progesterone (CAS 1096-38-4)
- Progesterone EP Impurity A (CAS 24377-08-0)
Recommended Standards
- Ceritinib Impurity 18 (CAS CATO-C4X-1048918)
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- Pregnenolone Impurity 13 (CAS 566-65-4)
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- ethyl (2Z)-2-cyano-3-hydroxy-3-(4-methylphenyl)prop-2-enoate (CAS 91024-54-3)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com