Nintedanib Impurity 152 CAS CATO-C4X-1814152
| CAS No. | CATO-C4X-1814152 |
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nintedanib Impurity 152 (C10H11Cl3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Nintedanib Impurity 152 (CAS CATO-C4X-1814152), a pharmacopoeial impurity reference standard (molecular formula C10H11Cl3O3, MW 285.55 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 152 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11Cl3O3 |
| Molecular Weight | 285.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 140 (CAS CATO-C4X-1814140)
- Nintedanib Impurity 150 (CAS CATO-C4X-1814150)
- Nintedanib Impurity 151 (CAS CATO-C4X-1814151)
- Nintedanib Impurity 153 (CAS CATO-C4X-1814153)
- Nintedanib Impurity 124 (CAS CATO-C4X-1814124)
- Nintedanib Nintedanib Impurity 88 (CAS CATO-C4X-181488)
- Nintedanib Impurity 108 (CAS CATO-C4X-1814110)
- Nintedanib Impurity 75 (CAS 1253768-91-0)
Recommended Standards
- 6-Bromo-1-chloro-2-ethoxynaphthalene (CAS 1394291-31-6)
- 3-Chloro-2,6-dinitro-4-(trifluoromethyl)benzenamine (CAS 959235-57-5)
- 5-Bromo-6-chloro-N-methylpyridine-3-sulfonamide (CAS 622814-92-0)
- 6-Bromo-1-(chloromethyl)-2-methoxynaphthalene (CAS 92643-16-8)
- Valaciclovir Impurity 45 (CAS CATO-C4X-124845)
- Dapagliflozin Impurity 89 (CAS CATO-C4X-113889)
- Sofosbuvir Impurity 27 (CAS CATO-C4X-105227)
- 1-(3,4-Dimethylphenyl)cyclopentane-1-carboxylic acid (CAS 854414-87-2)
- 6-Bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 105655-01-4)
- 1-(2-Methoxyethyl)pyrrolidine-3-carboxylic acid hydrate (CAS 1609400-89-6)
- 4-{[2-(Trifluoromethyl)phenoxy]methyl}piperidine hydrochloride 614731-26-9 6721AE C13H17ClF3NO (CAS 614731-26-9)
- 5-Phenyl-2-(pyrrolidin-2-yl)-1H-imidazole (CAS 1118787-83-9)
- Nicotinamide impurity 28 (CAS CATO-C4X-200028)
- Liraglutide(3-31)TFA Salt (CAS CATO-C4X-19921)
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