(3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid CAS 1451393-40-0
| CAS No. | 1451393-40-0 |
| Molecular Formula | C7H5BClF3O3 |
| Molecular Weight | 240.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid (CAS 1451393-40-0), a certified reference material (molecular formula C7H5BClF3O3, MW 240.37 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 240.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (3-Chloro-5-(trifluoromethoxy)phenyl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BClF3O3 |
| Molecular Weight | 240.37 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-5-(trifluoromethoxy)phenylboronic Acid (CAS 1022922-16-2)
- (4-Chloro-2-(trifluoromethoxy)phenyl)boronic acid (CAS 1095990-65-0)
- 3-Chloro-2-(trifluoromethoxy)phenylboronic acid (CAS 1942072-67-4)
- (2-Chloro-4-trifluoromethoxyphenyl)boronic Acid (CAS 345226-20-2)
- (3-Chloro-4-(trifluoromethoxy)phenyl)boronic acid (CAS 870822-79-0)
- [5-Chloro-2-(trifluoromethoxy)phenyl]boronic acid (CAS 870822-78-9)
- 2-Chloro-6-(trifluoromethoxy)phenylboronic acid (CAS 2036084-49-6)
- 3-Chloro-2-hydroxy-4-(trifluoromethyl)phenylboronic acid (CAS 2121512-08-9)
Recommended Standards
- (S)-2-Amino-N-isopropyl-N-((3-methylthiophen-2-yl)methyl)propanamide (CAS 1354009-18-9)
- N1-Isopropyl-N1-((3-(methylthio)pyrazin-2-yl)methyl)ethane-1,2-diamine (CAS 1353980-48-9)
- 1-(4-Methylmorpholin-2-yl)-N-((3-methylthiophen-2-yl)methyl)methanamine (CAS 1311749-21-9)
- (S)-2-Amino-N,3-dimethyl-N-((3-methylthiophen-2-yl)methyl)butanamide (CAS 1307223-86-4)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-oxo-4-(tritylamino)butanoic acid (CAS 2044711-09-1)
- 5-(3-Methylphenoxymethyl)-1,3,4-oxadiazole-2-thiol (CAS 66178-72-1)
- 3-Methyl-2-(piperidin-4-yl)pyridine (CAS 821768-08-5)
- 4-aminothieno[3,2-c]pyridine-7-carboxamide (CAS 55040-50-1)
- 2-Methyl-5-(trifluoromethoxy)-1H-indole (CAS 900182-99-2)
- N,N'-Bis[2-(mesitoyl)-3-oxobutylidene]-(1R,2R)-1,2-diphenylethylenediaminato Cobalt(II) (CAS 212250-92-5)
- (R)-6-(4-Bromophenyl)-4-((S)-1-phenylethyl)morpholin-3-one (CAS 920801-93-0)
- 4-(2-{[(2,4-dichlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-yl)morpholine (CAS 339017-82-2)
- 4-({[3-cyano-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-2-yl]sulfanyl}methyl)benzoic acid (CAS 664994-28-9)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com