3,5-Bis(trifluoromethyl)benzylboronic acid CAS 1451393-52-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3,5-Bis(trifluoromethyl)benzylboronic acid.

3,5-Bis(trifluoromethyl)benzylboronic acid (CAS 1451393-52-4) is a high-purity analytical reference standard with the molecular formula C9H7BF6O2 and a molecular weight of 271.95 g/mol.

3,5-Bis(trifluoromethyl)benzylboronic acid (C9H7BF6O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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