Entacapone EP Impurity A (cis-Entacapone) CAS 145195-63-7
| CAS No. | 145195-63-7 |
| Molecular Formula | C14H15N3O5 |
| Molecular Weight | 305.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Entacapone EP Impurity A (cis-Entacapone) (CAS 145195-63-7, C14H15N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Entacapone EP Impurity A (cis-Entacapone) (C14H15N3O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 305.29 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15N3O5 |
| Molecular Weight | 305.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 3 |
Related Entacapone Standards
- Entacapone (CAS 130929-57-6)
- Entacapone Impurity 1 (CAS 100644-89-1)
- Entacapone Impurity 23 (CAS 1185241-19-3)
- Entacapone impurity 19 (CAS CATO-C4X-162919)
- Entacapone Impurity 56 (CAS CATO-C4X-162956)
- Entacapone EP Impurity H (CAS 1150310-15-8)
- Entacapone Impurity 12 (CAS CATO-C4X-162912)
- Entacapone EP Impurity I (CAS 1364322-42-8)
Recommended Standards
- ethyl (2Z)-[1-(4-fluorophenyl)-3,5-dimethyl-1H-pyrazol-4-yl](hydroxyimino)acetate (CAS 1006481-95-3)
- Ibrutinib Impurity 182 (CAS CATO-C4X-1064182)
- N-(4-Fluorobenzyl)-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)propanamide (CAS 1105228-48-5)
- Tert-butyl (2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate (CAS 864539-94-6)
- Dopamine Impurity 33 (CAS CATO-C4X-190833)
- Ozanimod Impurity 29 (CAS CATO-C4X-29029)
- Finerenone Impurity 96 (CAS CATO-C4X-288096)
- Mirtazapine Impurity 28 HCl (CAS CATO-C4X-151128)
- 5-Cyclopropoxy-6-iodonicotinonitrile (CAS 1243472-44-7)
- 2-Fluoro-N-(3-methoxy-1-methyl-1H-pyrazol-4-yl)-9-methyl-9H-purin-6-amine (CAS 1776113-94-0)
- 1-Allyl-1H-indole-3-carbonitrile (CAS 1263210-96-3)
- Dabigatran Impurity 9 (CAS 1381757-44-3)
- 2-(3-(Hydroxymethyl)pyrrolidin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one (CAS 1251159-63-3)
- Characteristic MSH-Tetrapeptide (CAS 4289-02-5)
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