Entacapone EP Impurity H CAS 1150310-15-8
| CAS No. | 1150310-15-8 |
| Molecular Formula | C15H15N3O5 |
| Molecular Weight | 317.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Entacapone EP Impurity H (CAS 1150310-15-8, C15H15N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Entacapone EP Impurity H (C15H15N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 317.30 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C15H15N3O5 |
| Molecular Weight | 317.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 3 |
Related Entacapone Standards
- Entacapone impurity 19 (CAS CATO-C4X-162919)
- Entacapone Impurity 56 (CAS CATO-C4X-162956)
- Entacapone Impurity 23 (CAS 1185241-19-3)
- Entacapone Impurity 21 (CAS 158693-04-0)
- Entacapone Impurity 22 (CAS 857629-78-8)
- Entacapone Impurity 9 (CAS 146698-91-1)
- Entacapone Impurity 11 (CAS CATO-C4X-162911)
- Entacapone Impurity 10 (CAS CATO-C4X-162910)
Recommended Standards
- Letrozole Impurity 12 (CAS CATO-C4X-182912)
- Letrozole Impurity 13 (CAS CATO-C4X-182913)
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- Morinidazole Impurity 40 (CAS CATO-C4X-219640)
- Bumetanide Impurity 100 (CAS CATO-C4X-1986100)
- Crisaborole impurity 160 (CAS CATO-C4X-2021160)
- Azilsartan Impurity 121 (CAS CATO-C4X-1096121)
- Bendamustine USP Related Compound H (CAS 1228551-91-4)
- 1-[(1-Ethyl-1H-pyrazol-3-yl)carbonyl]-4-methylpiperazine (CAS 1170588-14-3)
- Methyl 2-(5-fluoro-1H-indol-1-yl)acetate (CAS 1343059-96-0)
- Methyl 3-nitro-4-sulfanylbenzoate (CAS 59515-34-3)
- 5-Bromo-2-hydroxy-4-methoxybenzonitrile (CAS 1379779-22-2)
- 4-(BRomomethyl)-5-methyl-1h-imidazole hydrobromide (CAS 66187-97-1)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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