Ibrutinib Impurity 182 CAS CATO-C4X-1064182
| CAS No. | CATO-C4X-1064182 |
| Molecular Formula | C16H11N5O2 |
| Molecular Weight | 305.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Ibrutinib Impurity 182 (CAS CATO-C4X-1064182) is a certified pharmaceutical impurity reference standard with the molecular formula C16H11N5O2 and a molecular weight of 305.29 g/mol.
Ibrutinib Impurity 182 (C16H11N5O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H11N5O2 |
| Molecular Weight | 305.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 5 |
Related Ibrutinib Standards
- Ibrutinib Impurity 124 (CAS CATO-C4X-1064124)
- Ibrutinib Impurity 180 (CAS CATO-C4X-1064180)
- Ibrutinib Impurity 166 (CAS CATO-C4X-1064166)
- Ibrutinib Impurity 46 (CAS 330786-24-8)
- Ibrutinib Impurity 85 (CAS CATO-C4X-106485)
- Ibrutinib Impurity 86 (CAS CATO-C4X-106486)
- Ibrutinib Impurity 7 (CAS CATO-C4X-10647)
- Ibrutinib Impurity 67 (CAS 2134109-10-5)
Recommended Standards
- Tert-butyl (2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)carbamate (CAS 864539-94-6)
- Entacapone (CAS 130929-57-6)
- N-(3-cyanophenyl)-2-(1,3-dioxoisoindolin-2-yl)acetamide (CAS 709011-36-9)
- Entacapone EP Impurity A (cis-Entacapone) (CAS 145195-63-7)
- Ceftriaxone EP Impurity A (CAS 92143-31-2)
- Solifenacin Impurity 8 (CAS CATO-C4X-10538)
- Lidocaine EP Impurity A (CAS 87-62-7)
- Dilaurin (CAS 27638-00-2)
- 3-(3-ethoxypropyl)-1-[(4-methoxyphenyl)methyl]thiourea (CAS 1235440-55-7)
- 3-Iodo-1-isopropyl-1H-indole-2-carboxylic acid (CAS 1263209-55-7)
- TCS 5861528 (CAS 332117-28-9)
- 4-Bromo-2-(difluoromethyl)-5-fluoro-3-methoxypyridine (CAS 1806063-59-1)
- 1-(5,6-Dihydroxy-2,7-dimethylbenzofuran-3-yl)ethanone (CAS 709640-99-3)
- [Tyr0] Fibrinopeptide A, human (CAS 103226-11-5)
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