Dextromethorphan EP Impurity D CAS 1453167-99-1
| CAS No. | 1453167-99-1 |
| Molecular Formula | C18H25NO |
| Molecular Weight | 271.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dextromethorphan EP Impurity D (C18H25NO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Dextromethorphan EP Impurity D (CAS 1453167-99-1) is a certified pharmaceutical impurity reference standard with the molecular formula C18H25NO and a molecular weight of 271.40 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H25NO |
| Molecular Weight | 271.40 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 1 |
Related Dextromethorphan Standards
- Dextromethorphan impurity 23 (CAS 125-70-2)
- (6aS)-Dextromethorphan Impurity 9 (CAS CATO-C4X-11579)
- Dextromethorphan Impurity 15 (CAS 51072-34-5)
- Dextromethorphan-D3 (CAS 524713-56-2)
- Dextromethorphan Impurity 11 (CAS 28973-48-0)
- Dextromethorphan Impurity 12 (CAS 51745-05-2)
- Dextromethorphan Impurity 14 (Mixture of Rotamers) (CAS 29144-31-8)
- Dextromethorphan Impurity 21 (CAS 51773-23-0)
Recommended Standards
- Lauroylsarcosine (CAS 97-78-9)
- Albendazole Impurity 21 (CAS 20735-00-6)
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- N-[(5-phenylthiophen-2-yl)methyl]cyclohexanamine (CAS 1152881-01-0)
- Ledipasvir Impurity 38 (CAS CATO-C4X-331338)
- Olmesartan impurity 7 (CAS 144690-33-5)
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- 4-Bromo-2-cyclopentylphenol (CAS 55910-44-6)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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