Atogepant Impurity 3 CAS 1455358-11-8
| CAS No. | 1455358-11-8 |
| Molecular Formula | C18H20ClN3O2 |
| Molecular Weight | 345.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atogepant Impurity 3.
Atogepant Impurity 3 (CAS 1455358-11-8) is a certified pharmaceutical impurity reference standard with the molecular formula C18H20ClN3O2 and a molecular weight of 345.82 g/mol.
The molecular framework of Atogepant Impurity 3 (C18H20ClN3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Atogepant Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20ClN3O2 |
| Molecular Weight | 345.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Atogepant Standards
- Atogepant Impurity 77 (CAS CATO-C4X-328577)
- Atogepant Impurity 11 (CAS CATO-C4X-328511)
- Atogepant Impurity 84 (CAS CATO-C4X-328584)
- Atogepant Impurity 35 (CAS 1456803-47-6)
- Atogepant Impurity 36 (CAS CATO-C4X-328536)
- Atogepant Impurity 85 (CAS 3003751-92-3)
- Atogepant Impurity N17 (CAS 1455358-16-3)
- Atogepant Impurity 76 (CAS CATO-C4X-328576)
Recommended Standards
- Peficitinib Impurity 30 (CAS CATO-C4X-280730)
- Peficitinib Impurity 27 (CAS CATO-C4X-280727)
- 4-(((2-Amino-6-methylpyrimidin-4-yl)amino)methyl)-1-(2-chlorobenzyl)pyrrolidin-2-one (CAS 2173637-30-2)
- N-[2-(4-Chlorophenoxy)phenyl]-4-methyl-1-piperazinecarboxamide (CAS 69478-73-5)
- Bisoprolol Impurity 84 (CAS CATO-C4X-124784)
- Omeprazole Impurity 20 (CAS CATO-C4X-125520)
- Perampanel Impurity 12 (CAS 543699-60-1)
- C-(5-Phenyl-isoxazol-3-yl)-methylamine (CAS 154016-47-4)
- 5-Methoxy-1-(p-tolyl)-1H-pyrazole-3-carboxylic acid (CAS 54709-09-0)
- (2,2-Difluoro-3,3-dimethylcyclopropyl)methanamine hydrochloride (CAS 1955514-92-7)
- 2-Chloro-6,7-dimethoxyquinoline (CAS 68236-22-6)
- Methyl (3R,4S)-4-(4-fluorophenyl)pyrrolidine-3-carboxylate (CAS 1187930-65-9)
- 6-Bromo-2,3-dimethylaniline (CAS 84483-20-5)
- Peptide Impurity 82 (CAS 10491-78-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com