Latanoprost EP Impurity E CAS 145773-22-4
| CAS No. | 145773-22-4 |
| Molecular Formula | C26H40O5 |
| Molecular Weight | 432.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Latanoprost EP Impurity E (CAS 145773-22-4, C26H40O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C26H40O5, Latanoprost EP Impurity E contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 432.59 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Latanoprost EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H40O5 |
| Molecular Weight | 432.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
Related Latanoprost Standards
- Latanoprost Impurity 19 (CAS CATO-C4X-194119)
- Latanoprost EP Impurity F (CAS 913258-34-1)
- Latanoprost (CAS 130209-82-4)
- Latanoprost Impurity 14 (CAS CATO-C4X-194114)
- Latanoprost Impurity 15 (CAS CATO-C4X-194115)
- Latanoprost Impurity 28 (CAS CATO-C4X-194128)
- Latanoprost Impurity 30 (CAS CATO-C4X-194130)
- 2-Nor Latanoprost (CAS CATO-C4X-19414)
Recommended Standards
- trans-(15S)-Latanoprost (CAS 1235141-39-5)
- Simvastatin EP Impurity N (Mixture of Diastereomers) (CAS 774611-54-0)
- (4S,4′S)-2,2′-(1R)-[1,1′-Biphenyl]-2,2′-diylbis[4,5-dihydro-4-(2-methylpropyl)oxazole] (CAS 1428785-63-0)
- Simvastatin EP Impurity J (CAS 864357-88-0)
- Olaparib impurity 144 (CAS CATO-C4X-1135144)
- Milnacipran Impurity 44 (CAS 105310-28-9)
- (R,R)-Indacaterol Impurity 25 (CAS 753498-27-0)
- (Z)-4-Ethylidene-5-methyl-3-(propan-2-ylidene)pyrrolidin-2-one (CAS 37817-28-0)
- 4-(Difluoromethyl)-6-methylpyridin-2-amine (CAS 1805960-63-7)
- 1-(((4-Chlorophenoxy)carbonyl)oxy)ethyl isobutyrate (CAS 1622940-14-0)
- Naphthalen-2-ylphosphane (CAS 746545-23-3)
- (2E)-1-(4-Methoxyphenyl)-3-(4-methylphenyl)prop-2-en-1-one (CAS 41564-65-2)
- Ethyl 2-((3-hydroxypiperidin-1-yl)methyl)furan-3-carboxylate (CAS 1252434-71-1)
- β-Bag Cell Peptide (Aplysia californica) (CAS 109024-47-7)
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