Brexpiprazole impurity 124 CAS 146121-18-8
| CAS No. | 146121-18-8 |
| Molecular Formula | C12H12ClNO2 |
| Molecular Weight | 237.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Brexpiprazole impurity 124 (CAS 146121-18-8, C12H12ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H12ClNO2, Brexpiprazole impurity 124 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 237.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Brexpiprazole impurity 124 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12ClNO2 |
| Molecular Weight | 237.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Brexpiprazole Standards
- Brexpiprazole Impurity 51 (CAS 79145-59-8)
- Brexpiprazole Impurity 20 (CAS 616227-75-9)
- Brexpiprazole Impurity 6 (CAS 1886188-97-1)
- Brexpiprazole Impurity 87 (CAS 62969-59-9)
- Brexpiprazole Impurity 16 (CAS 2116542-22-2)
- Brexpiprazole Impurity 161 (CAS CATO-C4X-1131161)
- Brexpiprazole Impurity 23 (CAS CATO-C4X-113123)
- Brexpiprazole Impurity 24 (CAS 2809183-06-8)
Recommended Standards
- 697793-63-8 2-Chloro-6,7-dimethoxy-4-methylquinoline DTXSID60651052 (CAS 697793-63-8)
- 58868-27-2 2-chloro-5,8-dimethoxy-4-methylquinoline DTXSID80296525 (CAS 58868-27-2)
- Lornoxicam Impurity 34 (CAS 1333316-61-2)
- 475481-99-3 4-(Chloromethyl)-2-(2-methoxyphenyl)-5-methyl-1,3-oxazole MFCD08457264 (CAS 475481-99-3)
- CMC2026 Impurity 1 (CAS CATO-C4X-22661)
- Atrasentan Impurity 32 (CAS 1059040-12-8)
- Moxifloxacin impurity 129 (CAS CATO-C4X-1074129)
- Methyl 3-amino-4-chlorobenzofuran-2-carboxylate (CAS 1139838-91-7)
- 3,4-Bis(dibromomethyl)benzonitrile (CAS 19047-19-9)
- 2-Chloro-6-morpholinopyrimidin-4-amine (CAS 330993-04-9)
- 6-Chloro-2,8-dimethylimidazo[1,2-b]pyridazine (CAS 17412-23-6)
- 4,5-Dimethylthiazole-2-carbohydrazide (CAS 1378656-93-9)
- Difluorodipyridin-2-ylmethane (CAS 1204295-70-4)
- Peptide Impurity 81 TFA (CAS CATO-CPTD788581)
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