2’-Hydroxy-5’-(trifluoromethoxy)acetophenone CAS 146575-64-6
| CAS No. | 146575-64-6 |
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2’-Hydroxy-5’-(trifluoromethoxy)acetophenone (CAS 146575-64-6), molecular formula C9H7F3O3 and molecular weight 220.15 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2’-Hydroxy-5’-(trifluoromethoxy)acetophenone is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 220.15 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 2’-Hydroxy-5’-(trifluoromethoxy)acetophenone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Hydroxy Standards
- Methyl 2-hydroxy-6-(trifluoromethyl)benzoate (CAS 1024605-95-5)
- Methyl 2-hydroxy-2-(2,4,5-trifluorophenyl)acetate (CAS 1036273-10-5)
- 2-(4-Hydroxy-3-(trifluoromethyl)phenyl)acetic acid (CAS 1042703-41-2)
- 2-Hydroxy-4’-(trifluoromethoxy)acetophenone (CAS 1148005-60-0)
- Methyl 4-hydroxy-3-(trifluoromethyl)benzoate (CAS 115933-50-1)
- 2-Hydroxy-4-methyl-6-(trifluoromethyl)nicotinamide (CAS 116548-07-3)
- (2s)-2-Hydroxy-2-[3-(trifluoromethyl)phenyl]acetic acid (CAS 1198319-99-1)
- Methyl 2-hydroxy-5-(trifluoromethyl)benzoate (CAS 1261478-26-5)
Recommended Standards
- 2-Methoxy-5-(trifluoromethoxy)benzaldehyde (CAS 145742-65-0)
- Methyl 6-amino-5-(trifluoromethyl)nicotinate (CAS 1476762-29-4)
- N-methyl-4-nitro-n-(trifluoromethyl)aniline (CAS 143490-25-9)
- 1-(3-Bromo-2-methylpropyl)piperidine (CAS 1478896-47-7)
- Tiagabine alcohol analog (CAS 847233-27-6)
- (EZ)-Kresoxim-4-hydroxy (free acid) (CAS 181373-11-5)
- 1-(3'-Methyl-[1,1'-biphenyl]-4-yl)ethan-1-one (CAS 76650-29-8)
- Methyl 6-Amino-4-indolecarboxylate (CAS 103956-00-9)
- 4-Fluoro-5-iodo-2-methoxybenzonitrile (CAS 1374358-37-8)
- (3S)-3-amino-3-(4-hydroxy-3-methylphenyl)propanoic acid (CAS 1027335-66-5)
- Sitafloxacin impurity 81 (CAS CATO-C4X-115581)
- 2-(Difluoromethoxy)-5-hydroxybenzothiazole (CAS 1261812-84-3)
- 2-(Bromomethyl)-5-fluoropyridine Hydrobromide (CAS 1186194-88-6)
- Semaglutide impurity 86 (CAS CATO-C4X-222686)
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