Sertraline Impurity 55 CAS 147250-57-5
| CAS No. | 147250-57-5 |
| Molecular Formula | C18H17Cl2NO |
| Molecular Weight | 334.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Sertraline Impurity 55 (CAS 147250-57-5, C18H17Cl2NO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Sertraline Impurity 55 (C18H17Cl2NO) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 334.24 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Sertraline Impurity 55 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17Cl2NO |
| Molecular Weight | 334.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sertraline Standards
- Sertraline Acetamide (CAS 1097616-52-8)
- Sertraline impurity 44 (CAS CATO-C4X-134444)
- Sertraline Impurity 60 (CAS CATO-C4X-134460)
- Sertraline Impurity 61 (CAS CATO-C4X-134461)
- Sertraline Impurity 62 (CAS CATO-C4X-134462)
- Sertraline Impurity 63 (CAS CATO-C4X-134463)
- Sertraline N-Oxide (CAS 209473-00-7)
- Sertraline RC 16 (CAS 674768-11-7)
Recommended Standards
- 898775-01-4 (3,5-Dichlorophenyl){2-[(pyrrolidin-1-yl)methyl]phenyl}methanone DTXSID80643671 (CAS 898775-01-4)
- Metoclopramide Impurity 21 (CAS 25195-05-5)
- N-(3,5-dichlorophenyl)-2-((5-methyl-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 306730-38-1)
- 8-(2-Nitro-4-(trifluoromethyl)phenoxy)quinoline (CAS 1020251-87-9)
- Dopamine Impurity 94 (CAS CATO-C4X-190894)
- Suvorexant Impurity 51 (CAS CATO-C4X-181251)
- Linagliptin impurity 140 (CAS 2428491-17-0)
- 4-Amino-2-methyl-2H-1,2,3-triazole (CAS 936940-63-5)
- 3-Bromo-6-methoxy-4-methyl-chromen-2-one (CAS 210772-04-6)
- 3,3'',6,6''-Tetra-tert-butyl-9'H-9,3':6',9''-tercarbazole (CAS 551951-04-3)
- 4-[[(1-Propyl-1H-imidazol-5-yl)methyl]sulfinyl]benzenamine (CAS 597583-07-8)
- N-(4-Methylthiazol-2-yl)-2-phenyl-2H-tetrazole-5-carboxamide (CAS 1396786-50-7)
- Tirzepatide Impurity 47 (CAS CATO-C4X-324047)
- Peptide T (CAS 106362-32-7)
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