Niraparib Impurity 6 CAS 1476777-06-6
| CAS No. | 1476777-06-6 |
| Molecular Formula | C19H19N3O2 |
| Molecular Weight | 321.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Niraparib Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Niraparib Impurity 6 (CAS 1476777-06-6), a pharmacopoeial impurity reference standard (molecular formula C19H19N3O2, MW 321.38 g/mol) used for the identification and quantification of trace impurities in APIs.
Niraparib Impurity 6 (C19H19N3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H19N3O2 |
| Molecular Weight | 321.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 3 |
Related Niraparib Standards
- Niraparib Impurity N1 (CAS 1038915-75-1)
- Niraparib R-enantiomer p-tosylate (CAS 1038915-58-0)
- Niraparib Impurity 40 (CAS CATO-C4X-232940)
- Niraparib Impurity 68 (CAS CATO-C4X-232968)
- Niraparib (CAS 1038915-60-4)
- Niraparib Impurity 28 (CAS 2308483-83-0)
- Niraparib Impurity 26 (CAS CATO-C4X-232926)
- Niraparib Impurity 33 (CAS CATO-C4X-232933)
Recommended Standards
- N-(5-phenethyl-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl)benzo[d]oxazol-2-amine (CAS 673490-60-3)
- Phenol, o-(phenylthio)-, carbanilate (6CI) (CAS 101895-33-4)
- N-(5-Cyano-2-(cyclohexylamino)pyrimidin-4-yl)benzamide (CAS 918662-98-3)
- (R)-3-(Benzo[b]thiophen-3-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid (CAS 111082-76-9)
- Cabazitaxel Impurity N1 (CAS 1354900-66-5)
- Riboflavin Impurity 29 (CAS CATO-C4X-181929)
- Pirfenidone Impurity 13 (CAS 2251047-36-4)
- 1244855-41-1 Methyl 4-{[(3,4-dimethoxybenzyl)amino]methyl}benzoate MFCD15732422 (CAS 1244855-41-1)
- 2,5-Difluoro-4-morpholinobenzoic acid (CAS 1430223-92-9)
- 4-Nitrophenyl 2-acetamido-6-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-3-O-(b-D-galactopyranosyl)-2-deoxy-α-D-galactopyranoside (CAS 139459-55-5)
- tert-Butyl 2-(2-bromophenyl)-2-oxoacetate (CAS 767288-73-3)
- (2-aminoethyl)[3-(3,4-dichlorophenoxy)-2-hydroxypropyl]amine (CAS 1274001-55-6)
- 1-Iodo-2-vinylbenzene (CAS 4840-91-9)
- Semaglutide Impurity 12 (CAS CATO-C4X-222612)
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