Niraparib Impurity 28 CAS 2308483-83-0
| CAS No. | 2308483-83-0 |
| Molecular Formula | C19H20N2O3 |
| Molecular Weight | 324.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Niraparib Impurity 28 (C19H20N2O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 324.37 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Niraparib Impurity 28 (CAS 2308483-83-0, C19H20N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Niraparib Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H20N2O3 |
| Molecular Weight | 324.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 2 |
Related Niraparib Standards
- Niraparib-d5 (CAS 1038915-60-4 (non-labelled))
- Niraparib Impurity 6 (CAS 1476777-06-6)
- Niraparib Impurity N1 (CAS 1038915-75-1)
- Niraparib R-enantiomer p-tosylate (CAS 1038915-58-0)
- Niraparib Impurity 40 (CAS CATO-C4X-232940)
- Niraparib Impurity 68 (CAS CATO-C4X-232968)
- Niraparib (CAS 1038915-60-4)
- Niraparib Impurity 26 (CAS CATO-C4X-232926)
Recommended Standards
- Proparacaine Impurity 36 (CAS CATO-C4X-202736)
- O-Desmethylpimobendan-D4 (CAS CATO-C4X-246112)
- Esmolol Impurity 92 (CAS CATO-C4X-189192)
- O-Desmethylpimobendan D4 (CAS CATO-C4X-246113)
- Ropinirole Impurity 5 (CAS CATO-C4X-17455)
- Brexpiprazole Impurity 21 (CAS 2059954-32-2)
- Phenylephrine Hydrochloride EP Impurity A HCl (R-Isomer) (CAS 636-87-3)
- Methyl 3-(4-oxo-7-(trifluoromethyl)quinolin-1(4H)-yl)propanoate (CAS 1279207-56-5)
- 2-(2-ethylhexyloxy)ethanol (CAS 1559-35-9)
- 4',4'-Dimethyl-3',4'-dihydro-2'H-spiro[cyclopropane-1,1'-naphthalen]-2-amine hydrochloride (CAS 1427380-49-1)
- 1,1'-((6-Hydrazono-1,6-dihydropyridazin-3-yl)azanediyl)bis(propan-2-ol) dihydrochloride (CAS 37007-70-8)
- 1-(2-Bromo-3-(trifluoromethyl)phenyl)propan-2-one (CAS 1806354-40-4)
- 4-azidoaniline (CAS 14860-64-1)
- Semaglutide Impurity 176 (CAS CATO-C4X-2226176)
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