5-Amino-2-chloro-6-(trifluoromethyl)pyrimidine-4(3H)-thione CAS 1480-67-7
| CAS No. | 1480-67-7 |
| Molecular Formula | C5H3ClF3N3S |
| Molecular Weight | 229.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 5-Amino-2-chloro-6-(trifluoromethyl)pyrimidine-4(3H)-thione (CAS 1480-67-7), a certified reference material (molecular formula C5H3ClF3N3S, MW 229.61 g/mol) for analytical method development and quality control.
Owing to a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution, 5-Amino-2-chloro-6-(trifluoromethyl)pyrimidine-4(3H)-thione is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 229.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3ClF3N3S |
| Molecular Weight | 229.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 5-Amino-6-chloro-2-(trifluoromethyl)-1H-pyrimidine-4-thione (CAS 1598-59-0)
- 4-(2-Amino-2-oxoethoxy)-3-chlorobenzoic acid (CAS 1004687-82-4)
- 8-Amino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid (CAS 148703-26-8)
- Ethyl 2-amino-4-chloro-5-methoxybenzoate (CAS 108494-83-3)
- 2-Amino-1-(8-chloro-2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-ol (CAS 1094248-62-0)
- Methyl 4-amino-5-chloro-2-ethoxybenzoate (CAS 112914-03-1)
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Recommended Standards
- 6-Chloro-2-(difluoromethyl)quinolin-4(1H)-one (CAS 1339490-19-5)
- 4-(Chloromethyl)-1-(2,3-difluorophenyl)-1H-1,2,3-triazole (CAS 1251343-79-9)
- 3-Chloro-4-(difluoromethyl)quinolin-2(1H)-one (CAS 1713713-47-3)
- 4-(Chloromethyl)-1-(3,4-difluorophenyl)-1H-1,2,3-triazole (CAS 1250228-16-0)
- (S)-Cyclopropyl(3-methoxyphenyl)methanamine (CAS 1213642-78-4)
- 6-Chloro-2-(3,5-dimethoxyphenyl)pyridazin-3(2H)-one (CAS 2095779-74-9)
- Bis(pentafluorophenyl)dimethylsilane (CAS 10536-62-6)
- 1-Bromo-3-ethynyl-2-methylbenzene (CAS 2228172-50-5)
- Pentafluorophenylhydrazine (CAS 828-73-9)
- N,N-Diethylheptan-1-amine (CAS 26981-81-7)
- (1S,2S)-2-(Difluoromethyl)cyclopropanecarboxylic acid (CAS 1820569-46-7)
- 4-(5-Formyl-4-methylpyridin-2-yl)piperazine-1-carbaldehyde (CAS 1355182-54-5)
- 2-Amino-3-(((benzyloxy)carbonyl)amino)propanoic acid (CAS 61177-01-3)
- D-Val23-Tirzepatide (CAS CATO-CPTD788911)
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