Pitavastatin Impurity 59 CAS 148516-15-8
| CAS No. | 148516-15-8 |
| Molecular Formula | C25H20FNO2 |
| Molecular Weight | 385.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Pitavastatin Impurity 59 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Pitavastatin Impurity 59 (CAS 148516-15-8, C25H20FNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Pitavastatin Impurity 59 (C25H20FNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Pitavastatin Impurity 59 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H20FNO2 |
| Molecular Weight | 385.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Pitavastatin Standards
- Pitavastatin Impurity 15 (CAS CATO-C4X-103715)
- Pitavastatin Impurity 4 (CAS 141750-63-2)
- Pitavastatin Impurity 74 (CAS CATO-C4X-103774)
- Pitavastatin Impurity 114 (CAS CATO-C4X-1037114)
- Pitavastatin Impurity 136 (CAS 1611991-87-7)
- Pitavastatin Impurity 21 (CAS 154057-56-4)
- Pitavastatin Impurity 42 (CAS CATO-C4X-103742)
- Pitavastatin Impurity 43 (CAS CATO-C4X-103743)
Recommended Standards
- N-[2-(Benzenesulfonyl)ethyl]-2-(4-fluorobenzenesulfonyl)acetamide (CAS 337923-51-0)
- Bisacodyl Impurity 13 (CAS CATO-C4X-203713)
- Ethyl 1-((4-methoxyphenyl)sulfonyl)-5-phenyl-1H-pyrrole-3-carboxylate (CAS 881673-36-5)
- N-(3-(3-(Furan-2-yl)-6-oxopyridazin-1(6H)-yl)propyl)-2-phenylethene-1-sulfonamide (CAS 1021253-79-1)
- Methionine EP Impurity D (CAS CATO-C4X-18276)
- Timolol Impurity 25 (CAS CATO-C4X-149625)
- Methotrexate Impurity 33 (CAS CATO-C4X-115433)
- (E)-2-(3-Methyl-2,4-dioxothiazolidin-5-ylidene)acetic acid (CAS 90137-11-4)
- Lansoprazole impurity 73 (CAS CATO-C4X-111373)
- 4-Chloro-6-(cyclopentyloxy)pyrimidine (CAS 405931-42-2)
- Glucoraphanin (CAS 21414-41-5)
- 5-Methyl-4-nitro-1-(2-(trifluoromethyl)phenyl)-1H-1,2,3-triazole (CAS 861212-68-2)
- 3,6-Difluorobenzene-1,2-diol (CAS 75626-23-2)
- Peptide 431 (CAS CATO-CPTD788431)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com