Pitavastatin Impurity 21 CAS 154057-56-4
| CAS No. | 154057-56-4 |
| Molecular Formula | C19H15BrFN |
| Molecular Weight | 356.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Pitavastatin Impurity 21 (CAS 154057-56-4), a pharmacopoeial impurity reference standard (molecular formula C19H15BrFN, MW 356.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution, Pitavastatin Impurity 21 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 356.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pitavastatin Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H15BrFN |
| Molecular Weight | 356.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Pitavastatin Standards
- Pitavastatin Impurity 42 (CAS CATO-C4X-103742)
- Pitavastatin Impurity 43 (CAS CATO-C4X-103743)
- Pitavastatin Impurity 41 (CAS CATO-C4X-103741)
- Pitavastatin Impurity 18 (CAS 148516-11-4)
- Pitavastatin Impurity 78 (CAS CATO-C4X-103778)
- Pitavastatin Impurity 59 (CAS 148516-15-8)
- Pitavastatin Impurity 40 (CAS 121659-86-7)
- Pitavastatin Impurity 15 (CAS CATO-C4X-103715)
Recommended Standards
- N-Benzyl 5-bromo-2-methoxybenzenesulfonamide (CAS 446308-82-3)
- N-(4-Bromobenzyl)-2-methoxybenzenesulfonamide (CAS 864685-53-0)
- N-(4-Bromo-2-(hydroxymethyl)phenyl)-4-methylbenzenesulfonamide (CAS 329281-02-9)
- 4-Bromo-1-[4-(1-pyrrolidinylsulfonyl)phenyl]-1H-pyrazole (CAS 1187385-91-6)
- Ceftazidime Impurity 74 (CAS CATO-C4X-121274)
- Lusutrombopag Impurity 71 (CAS CATO-C4X-208471)
- Caspofungin Impurity 14 (CAS CATO-C4X-157514)
- N-Cyclohexyl-2-methoxybenzamide (CAS 57149-81-2)
- methyl 6-chloro-2-((4-methoxybenzyl)amino)nicotinate (CAS 1356353-33-7)
- Ethyl bicyclo[3.3.1]non-6-ene-2-carboxylate (CAS 1005254-20-5)
- 3-(Bromomethyl)-2H,3H,5H-[1,3]thiazolo[2,3-b]quinazolin-5-one (CAS 212143-50-5)
- 5-(2-Aminothiazol-4-yl)quinolin-8-ol (CAS 679390-92-2)
- 3-(1-Chloroethyl)pyridine (CAS 38835-88-0)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788679)
Why CATO?
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