Econazole Impurity 8 CAS 14866-28-5
| CAS No. | 14866-28-5 |
| Molecular Formula | C8H8Cl2O2 |
| Molecular Weight | 207.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Econazole Impurity 8 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Econazole Impurity 8 (CAS 14866-28-5, C8H8Cl2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Econazole Impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 207.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Econazole Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H8Cl2O2 |
| Molecular Weight | 207.05 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related Econazole Standards
- Econazole Impurity 12 (CAS 45892-47-5)
- Econazole Impurity 13 (CAS 88965-93-9)
- Econazole Impurity 4 (CAS 137958-96-4)
- Econazole impurity 27 (CAS 27087-94-1)
- Econazole impurity 29 (CAS 24155-32-6)
- Econazole impurity 17 (CAS 24155-44-0)
- Econazole impurity 18 (CAS 24155-45-1)
- Econazole Impurity 11 (CAS 4252-78-2)
Recommended Standards
- Tadalafil Impurity 163 (CAS CATO-C4X-1087163)
- Chloroneb (CAS 2675-77-6)
- 5-Bromothiazole-2-carboxamide (CAS 957345-64-1)
- 2,4-Dichloro-6-isopropoxypyrimidine (CAS 1026787-89-2)
- Solriamfetol Impurity 24 (CAS CATO-C4X-256324)
- Sofosbuvir Impurity 71 (CAS CATO-C4X-105271)
- Naloxone Impurity 19 (CAS CATO-C4X-149319)
- 2-(Piperidin-1-yl)-2-(4-(trifluoromethoxy)phenyl)acetic acid (CAS 1218439-39-4)
- 7,8-Dihydro-a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine Hydrochloride (CAS 1622173-72-1)
- 1-(p-tolylsulfonyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidine (CAS 1382358-37-3)
- 2-Hydroxy-7-methoxy-1-naphthaldehyde (CAS 75965-66-1)
- (R)-Methyl 2-methyl-5-oxopyrrolidine-1-carboxylate (CAS 247233-47-2)
- Methyl 2-(2-amino-4,5-dihydro-1H-imidazol-1-yl)acetate (CAS 775517-90-3)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com