Gimeracil impurity 12 CAS 149143-68-0
| CAS No. | 149143-68-0 |
| Molecular Formula | C6H3ClN2O2 |
| Molecular Weight | 170.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Gimeracil impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Gimeracil impurity 12 (CAS 149143-68-0) is a certified pharmaceutical impurity reference standard with the molecular formula C6H3ClN2O2 and a molecular weight of 170.55 g/mol.
Gimeracil impurity 12 (C6H3ClN2O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN2O2 |
| Molecular Weight | 170.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Gimeracil Standards
Recommended Standards
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- 6-Chlorooxazolo[4,5-β]pyridin-2(3H)-one (CAS 35570-68-4)
- 6-Chloro-1H-purin-2(3H)-one (CAS 1146697-79-1)
- Troxipide Impurity 11 (CAS CATO-C4X-214811)
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- Sulpiride EP Impurity C (CAS 33045-53-3)
- 3-(1-(4-Bromophenyl)-1H-pyrazol-4-yl)propanoic Acid (CAS 1782372-58-0)
- N-Butyl-1,4-dimethyl-1H-pyrazol-3-amine hydrochloride (CAS 1856093-05-4)
- 2-(Naphthalen-1-ylmethoxy)-1-naphthaldehyde (CAS 692771-20-3)
- 5-(4-Iodophenyl)-10,15,20-triphenyl-21H,23H-porphine (CAS 133513-05-0)
- tert-Butyl 2-(Aminomethyl)-4-methylbenzylcarbamate (CAS 862205-35-4)
- Chlorophyll (contains 0.5% Chlorophylls) Discontinued See: C379880 and C379875. (CAS 1406-65-1)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788692)
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